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@ARTICLE{Rostami:290171,
      author       = {S. Rostami and T. B. Rounge and L. Pestarino and R. Lyle
                      and R. T. Fortner$^*$ and Ø. A. Haaland and R. T. Lie and
                      F. Wiklund and T. Bjørge and H. Langseth},
      title        = {{D}ifferential levels of circulating {RNA}s prior to
                      endometrial cancer diagnosis.},
      journal      = {International journal of cancer},
      volume       = {155},
      number       = {5},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01007},
      pages        = {946-956},
      year         = {2024},
      note         = {2024 Sep 1;155(5):946-956},
      abstract     = {Endometrial cancer (EC) is one of the most common female
                      cancers and there is currently no routine screening strategy
                      for early detection. An altered abundance of circulating
                      microRNAs (miRNAs) and other RNA classes have the potential
                      as early cancer biomarkers. We analyzed circulating RNA
                      levels using small RNA sequencing, targeting RNAs in the
                      size range of 17-47 nucleotides, in EC patients with samples
                      collected prior to diagnosis compared to cancer-free
                      controls. The analysis included 316 cases with samples
                      collected 1-11 years prior to EC diagnosis, and 316 matched
                      controls, both from the Janus Serum Bank cohort in Norway.
                      We identified differentially abundant (DA) miRNAs, isomiRs,
                      and small nuclear RNAs between EC cases and controls. The
                      top EC DA miRNAs were miR-155-5p, miR-200b-3p, miR-589-5p,
                      miR-151a-5p, miR-543, miR-485-5p, miR-625-p, and miR-671-3p.
                      miR-200b-3p was previously reported to be among one of the
                      top miRNAs with higher abundance in EC cases. We observed
                      47, 41, and 32 DA miRNAs for EC interacting with BMI,
                      smoking status, and physical activity, respectively,
                      including two miRNAs (miR-223-3p and miR-29b-3p) interacting
                      with all three factors. The circulating RNAs are altered and
                      show temporal dynamics prior to EC diagnosis. Notably, DA
                      miRNAs for EC had the lowest q-value 4.39-6.66 years before
                      diagnosis. Enrichment analysis of miRNAs showed that
                      signaling pathways Fc epsilon RI, prolactin, toll-like
                      receptor, and VEGF had the strongest associations.},
      keywords     = {RNA (Other) / RNA‐sequencing (Other) / cell‐free
                      nucleic acids (Other) / endometrial neoplasms (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38733362},
      doi          = {10.1002/ijc.34951},
      url          = {https://inrepo02.dkfz.de/record/290171},
}