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000290220 1001_ $$aPapadimitriou, Nikos$$b0
000290220 245__ $$aGenome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer.
000290220 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2024
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000290220 520__ $$aConsumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations.A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1--degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction simultaneously.The 3-DF joint test revealed two significant loci with p-value <5 × 10-8. Rs4730274 close to the SLC26A3 gene showed an association with fibre (p-value: 2.4 × 10-3) and G × fibre interaction with CRC (OR per quartile of fibre increase = 0.87, 0.80, and 0.75 for CC, TC, and TT genotype, respectively; G × E p-value: 1.8 × 10-7). Rs1620977 in the NEGR1 gene showed an association with fruit intake (p-value: 1.0 × 10-8) and G × fruit interaction with CRC (OR per quartile of fruit increase = 0.75, 0.65, and 0.56 for AA, AG, and GG genotype, respectively; G × E -p-value: 0.029).We identified 2 loci associated with fibre and fruit intake that also modify the association of these dietary factors with CRC risk. Potential mechanisms include chronic inflammatory intestinal disorders, and gut function. However, further studies are needed for mechanistic validation and replication of findings.National Institutes of Health, National Cancer Institute. Full funding details for the individual consortia are provided in acknowledgments.
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000290220 650_7 $$2Other$$aColorectal cancer
000290220 650_7 $$2Other$$aDiet
000290220 650_7 $$2Other$$aFibre
000290220 650_7 $$2Other$$aGWAS
000290220 650_7 $$2Other$$aGene-environment interaction
000290220 7001_ $$aKim, Andre$$b1
000290220 7001_ $$aKawaguchi, Eric S$$b2
000290220 7001_ $$aMorrison, John$$b3
000290220 7001_ $$aDiez-Obrero, Virginia$$b4
000290220 7001_ $$aAlbanes, Demetrius$$b5
000290220 7001_ $$aBerndt, Sonja I$$b6
000290220 7001_ $$aBézieau, Stéphane$$b7
000290220 7001_ $$aBien, Stephanie A$$b8
000290220 7001_ $$aBishop, D Timothy$$b9
000290220 7001_ $$aBouras, Emmanouil$$b10
000290220 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b11$$udkfz
000290220 7001_ $$aBuchanan, Daniel D$$b12
000290220 7001_ $$aCampbell, Peter T$$b13
000290220 7001_ $$aCarreras-Torres, Robert$$b14
000290220 7001_ $$aChan, Andrew T$$b15
000290220 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b16$$udkfz
000290220 7001_ $$aConti, David V$$b17
000290220 7001_ $$aDevall, Matthew A$$b18
000290220 7001_ $$aDimou, Niki$$b19
000290220 7001_ $$aDrew, David A$$b20
000290220 7001_ $$aGruber, Stephen B$$b21
000290220 7001_ $$aHarrison, Tabitha A$$b22
000290220 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b23$$udkfz
000290220 7001_ $$aHuyghe, Jeroen R$$b24
000290220 7001_ $$aJoshi, Amit D$$b25
000290220 7001_ $$aKeku, Temitope O$$b26
000290220 7001_ $$aKundaje, Anshul$$b27
000290220 7001_ $$aKüry, Sébastien$$b28
000290220 7001_ $$aLe Marchand, Loic$$b29
000290220 7001_ $$aLewinger, Juan Pablo$$b30
000290220 7001_ $$aLi, Li$$b31
000290220 7001_ $$aLynch, Brigid M$$b32
000290220 7001_ $$aMoreno, Victor$$b33
000290220 7001_ $$aNewton, Christina C$$b34
000290220 7001_ $$aObón-Santacana, Mireia$$b35
000290220 7001_ $$aOse, Jennifer$$b36
000290220 7001_ $$aPellatt, Andrew J$$b37
000290220 7001_ $$aPeoples, Anita R$$b38
000290220 7001_ $$aPlatz, Elizabeth A$$b39
000290220 7001_ $$aQu, Conghui$$b40
000290220 7001_ $$aRennert, Gad$$b41
000290220 7001_ $$aRuiz-Narvaez, Edward$$b42
000290220 7001_ $$aShcherbina, Anna$$b43
000290220 7001_ $$aStern, Mariana C$$b44
000290220 7001_ $$aSu, Yu-Ru$$b45
000290220 7001_ $$aThomas, Duncan C$$b46
000290220 7001_ $$aThomas, Claire E$$b47
000290220 7001_ $$0P:(DE-He78)834e8bc4d74592e3b999100c157215f5$$aTian, Yu$$b48
000290220 7001_ $$aTsilidis, Konstantinos K$$b49
000290220 7001_ $$aUlrich, Cornelia M$$b50
000290220 7001_ $$aUm, Caroline Y$$b51
000290220 7001_ $$aVisvanathan, Kala$$b52
000290220 7001_ $$aWang, Jun$$b53
000290220 7001_ $$aWhite, Emily$$b54
000290220 7001_ $$aWoods, Michael O$$b55
000290220 7001_ $$aSchmit, Stephanie L$$b56
000290220 7001_ $$aMacrae, Finlay$$b57
000290220 7001_ $$aPotter, John D$$b58
000290220 7001_ $$aHopper, John L$$b59
000290220 7001_ $$aPeters, Ulrike$$b60
000290220 7001_ $$aMurphy, Neil$$b61
000290220 7001_ $$aHsu, Li$$b62
000290220 7001_ $$aGunter, Marc J$$b63
000290220 7001_ $$aGauderman, W James$$b64
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