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@ARTICLE{Papadimitriou:290220,
      author       = {N. Papadimitriou and A. Kim and E. S. Kawaguchi and J.
                      Morrison and V. Diez-Obrero and D. Albanes and S. I. Berndt
                      and S. Bézieau and S. A. Bien and D. T. Bishop and E.
                      Bouras and H. Brenner$^*$ and D. D. Buchanan and P. T.
                      Campbell and R. Carreras-Torres and A. T. Chan and J.
                      Chang-Claude$^*$ and D. V. Conti and M. A. Devall and N.
                      Dimou and D. A. Drew and S. B. Gruber and T. A. Harrison and
                      M. Hoffmeister$^*$ and J. R. Huyghe and A. D. Joshi and T.
                      O. Keku and A. Kundaje and S. Küry and L. Le Marchand and
                      J. P. Lewinger and L. Li and B. M. Lynch and V. Moreno and
                      C. C. Newton and M. Obón-Santacana and J. Ose and A. J.
                      Pellatt and A. R. Peoples and E. A. Platz and C. Qu and G.
                      Rennert and E. Ruiz-Narvaez and A. Shcherbina and M. C.
                      Stern and Y.-R. Su and D. C. Thomas and C. E. Thomas and Y.
                      Tian$^*$ and K. K. Tsilidis and C. M. Ulrich and C. Y. Um
                      and K. Visvanathan and J. Wang and E. White and M. O. Woods
                      and S. L. Schmit and F. Macrae and J. D. Potter and J. L.
                      Hopper and U. Peters and N. Murphy and L. Hsu and M. J.
                      Gunter and W. J. Gauderman},
      title        = {{G}enome-wide interaction study of dietary intake of fibre,
                      fruits, and vegetables with risk of colorectal cancer.},
      journal      = {EBioMedicine},
      volume       = {104},
      issn         = {2352-3964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01038},
      pages        = {105146},
      year         = {2024},
      abstract     = {Consumption of fibre, fruits and vegetables have been
                      linked with lower colorectal cancer (CRC) risk. A
                      genome-wide gene-environment (G × E) analysis was performed
                      to test whether genetic variants modify these associations.A
                      pooled sample of 45 studies including up to 69,734
                      participants (cases: 29,896; controls: 39,838) of European
                      ancestry were included. To identify G × E interactions, we
                      used the traditional 1--degree-of-freedom (DF) G × E test
                      and to improve power a 2-step procedure and a 3DF joint test
                      that investigates the association between a genetic variant
                      and dietary exposure, CRC risk and G × E interaction
                      simultaneously.The 3-DF joint test revealed two significant
                      loci with p-value <5 × 10-8. Rs4730274 close to the SLC26A3
                      gene showed an association with fibre (p-value: 2.4 × 10-3)
                      and G × fibre interaction with CRC (OR per quartile of
                      fibre increase = 0.87, 0.80, and 0.75 for CC, TC, and TT
                      genotype, respectively; G × E p-value: 1.8 × 10-7).
                      Rs1620977 in the NEGR1 gene showed an association with fruit
                      intake (p-value: 1.0 × 10-8) and G × fruit interaction
                      with CRC (OR per quartile of fruit increase = 0.75, 0.65,
                      and 0.56 for AA, AG, and GG genotype, respectively; G × E
                      -p-value: 0.029).We identified 2 loci associated with fibre
                      and fruit intake that also modify the association of these
                      dietary factors with CRC risk. Potential mechanisms include
                      chronic inflammatory intestinal disorders, and gut function.
                      However, further studies are needed for mechanistic
                      validation and replication of findings.National Institutes
                      of Health, National Cancer Institute. Full funding details
                      for the individual consortia are provided in
                      acknowledgments.},
      keywords     = {Colorectal cancer (Other) / Diet (Other) / Fibre (Other) /
                      GWAS (Other) / Gene-environment interaction (Other)},
      cin          = {C120 / C070 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38749303},
      doi          = {10.1016/j.ebiom.2024.105146},
      url          = {https://inrepo02.dkfz.de/record/290220},
}