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@ARTICLE{Tang:290332,
      author       = {K. Tang and Q. Sun and J. Zeng and J. Tang and P. Cheng and
                      Z. Qiu$^*$ and H. Long and Y. Chen and C. Zhang and J. Wei
                      and X. Qiu and G. Jiang and Q. Fang and L. Sun and C. Sun
                      and X. Du},
      title        = {{N}etwork-based approach for drug repurposing against
                      mpox.},
      journal      = {International journal of biological macromolecules},
      volume       = {270},
      number       = {Pt 2},
      issn         = {0141-8130},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01060},
      pages        = {132468},
      year         = {2024},
      abstract     = {The current outbreak of mpox presents a significant threat
                      to the global community. However, the lack of mpox-specific
                      drugs necessitates the identification of additional
                      candidates for clinical trials. In this study, a network
                      medicine framework was used to investigate poxviruses-human
                      interactions to identify potential drugs effective against
                      the mpox virus (MPXV). The results indicated that poxviruses
                      preferentially target hubs on the human interactome, and
                      that these virally-targeted proteins (VTPs) tend to
                      aggregate together within specific modules. Comorbidity
                      analysis revealed that mpox is closely related to immune
                      system diseases. Based on predicted drug-target
                      interactions, 268 drugs were identified using the network
                      proximity approach, among which 23 drugs displaying the
                      least side-effects and significant proximity to MPXV were
                      selected as the final candidates. Lastly, specific drugs
                      were explored based on VTPs, differentially expressed
                      proteins, and intermediate nodes, corresponding to different
                      categories. These findings provide novel insights that can
                      contribute to a deeper understanding of the pathogenesis of
                      MPXV and development of ready-to-use treatment strategies
                      based on drug repurposing.},
      keywords     = {Comorbidity (Other) / Drug repurposing (Other) / Mpox
                      (Other) / Virushost interaction (Other)},
      cin          = {E055},
      ddc          = {570},
      cid          = {I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38761900},
      doi          = {10.1016/j.ijbiomac.2024.132468},
      url          = {https://inrepo02.dkfz.de/record/290332},
}