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@ARTICLE{Belau:290338,
      author       = {M. H. Belau and L. Jung and T. Maurer and N. Obi and S.
                      Behrens$^*$ and P. Seibold$^*$ and H. Becher and J.
                      Chang-Claude$^*$},
      title        = {{S}ocial relationships and their impact on health-related
                      quality of life in a long-term breast cancer survivor
                      cohort.},
      journal      = {Cancer},
      volume       = {130},
      number       = {18},
      issn         = {0008-543X},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01066},
      pages        = {3210-3218},
      year         = {2024},
      note         = {#LA:C020# / 2024 Sep 15;130(18):3210-3218},
      abstract     = {Health-related quality of life (HRQOL) has become
                      increasingly important for breast cancer survivors, but
                      clinically relevant declines often persist for many years
                      after treatment. This study aimed to investigate whether
                      social relationships can mitigate or prevent this decline in
                      HRQOL.Data were used from the German population-based Mamma
                      Carcinoma Risk Factor Investigation (MARIE) cohort of 2022
                      breast cancer cases with follow-up information for more than
                      15 years after diagnosis. Correlations between social
                      integration, social support, and global health status (GHS)
                      as an overall measure of HRQOL were analyzed, and linear
                      regression analysis was performed with structural equation
                      modeling.The majority of participants reported high levels
                      of social integration and social support and moderate levels
                      of GHS. Social integration 5 years after diagnosis was
                      associated with GHS 5 years after diagnosis (β = 1.12;
                      $95\%$ CI, 0.25-1.99), but no longitudinal effects were
                      found. Social support 5 years after diagnosis was associated
                      with better GHS 5 years (β = 0.42; $95\%$ CI, 0.36-0.48)
                      and 10 years after diagnosis (β = 0.12; $95\%$ CI,
                      0.02-0.22), whereas social support 10 years after diagnosis
                      was associated with GHS 10 years (β = 0.29; $95\%$ CI,
                      0.20-0.39) and 15 years after diagnosis (β = 0.10; $95\%$
                      CI, 0.01-0.21).These results confirm that social
                      relationships positively influence HRQOL in long-term breast
                      cancer survivors and that their association should receive
                      more attention clinically and beyond routine care.},
      keywords     = {breast cancer (Other) / quality of life (Other) / social
                      networking (Other) / social support (Other) / survivorship
                      (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38758821},
      doi          = {10.1002/cncr.35364},
      url          = {https://inrepo02.dkfz.de/record/290338},
}