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@ARTICLE{Muoz:290347,
      author       = {I. D. Muñoz$^*$ and O. Van Hoey and A. Parisi and N.
                      Bassler and L. Grzanka and M. De Saint-Hubert and A. Vaniqui
                      and P. Olko and M. Sądel and L. Stolarczyk and A.
                      Vestergaard and O. Jaekel$^*$ and E. G. Yukihara and J. B.
                      Christensen},
      title        = {{A}ssessment of fluence- and dose-averaged linear energy
                      transfer with passive luminescence detectors in clinical
                      proton beams.},
      journal      = {Physics in medicine and biology},
      volume       = {69},
      number       = {13},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2024-01074},
      pages        = {135004},
      year         = {2024},
      note         = {#EA:E040#},
      abstract     = {This work investigates the use of passive luminescence
                      detectors to determine different types of averaged linear
                      energy transfer $(\overline{LET})$ for the energies relevant
                      to proton therapy. The experimental results are compared to
                      reference values obtained from Monte Carlo
                      simulations.Optically stimulated luminescence detectors
                      (OSLDs), fluorescent nuclear track detectors (FNTDs), and
                      two different groups of thermoluminescence detectors (TLDs)
                      were irradiated at four different radiation qualities. For
                      each irradiation, the fluence- $(\overline{LET}f)$ and
                      dose-averaged LET $(\overline{LET}d)$ were determined. For
                      both quantities, two sub-types of averages were calculated,
                      either considering contributions from primary and secondary
                      protons or from all protons and heavier charged particles.
                      Both simulated and experimental data were used in
                      combination with a phenomenological model to estimate the
                      relative biological effectiveness (RBE).All types of
                      $\overline{LET}$ could be assessed with the detectors. The
                      experimental determination of $\overline{LET}fis$ in
                      agreement with reference data obtained from simulations
                      across all measurement techniques and types of averaging. On
                      the other hand, $\overline{LET}dcan$ present challenges as a
                      radiation quality metric to describe the detector response
                      in mixed particle fields. However, excluding secondaries
                      heavier than protons from the $\overline{LET}dcalculation,$
                      as their contribution to the luminescence is suppressed by
                      ionization quenching, leads to equal accuracy between
                      $\overline{LET}fand$ $\overline{LET}d.$ Assessment of RBE
                      through the experimentally determined
                      $\overline{LET}dvalues$ agrees with independently acquired
                      reference values, indicating that the investigated detectors
                      can determine $\overline{LET}$ with sufficient accuracy for
                      proton therapy.OSLDs, TLDs, and FNTDs can be used to
                      determine $\overline{LET}$ and RBE in proton therapy. With
                      the capability to determine dose through ionization
                      quenching corrections derived from $\overline{LET},$ OSLDs
                      and TLDs can simultaneously ascertain dose,
                      $\overline{LET},$ and RBE. This makes passive detectors
                      appealing for measurements in phantoms, facilitating the
                      validation of clinical treatment plans or experiments
                      related to proton therapy.},
      keywords     = {FNTD (Other) / LET (Other) / Linear energy transfer (Other)
                      / Luminescence detectors (Other) / OSLD (Other) / TLD
                      (Other)},
      cin          = {E040},
      ddc          = {530},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38774985},
      doi          = {10.1088/1361-6560/ad4e8e},
      url          = {https://inrepo02.dkfz.de/record/290347},
}