TY  - JOUR
AU  - Gerhalter, Teresa
AU  - Schilling, Felix
AU  - Zeitouni, Nour
AU  - Linz, Peter
AU  - Baudin, Pierre-Yves
AU  - Kannenkeril, Dennis
AU  - Kopp, Christoph
AU  - Dahlmann, Anke
AU  - Schmieder, Roland
AU  - Uder, Michael
AU  - Nagel, Armin M
AU  - Gast, Lena V
TI  - Sodium quantification in skeletal muscle: comparison between Cartesian gradient-echo and radial ultra-short echo time 23Na MRI techniques.
JO  - European radiology experimental
VL  - 8
IS  - 1
SN  - 2509-9280
CY  - [Cham]
PB  - Springer International Publishing
M1  - DKFZ-2024-01080
SP  - 61
PY  - 2024
AB  - Clinical magnetic resonance imaging (MRI) studies often use Cartesian gradient-echo (GRE) sequences with  2-ms echo times (TEs) to monitor apparent total sodium concentration (aTSC). We compared Cartesian GRE and ultra-short echo time three-dimensional (3D) radial-readout sequences for measuring skeletal muscle aTSC.We retrospectively evaluated 211 datasets from 112 volunteers aged 62.3 ± 12.1 years (mean ± standard deviation), acquired at 3 T from the lower leg. For 23Na MRI acquisitions, we used a two-dimensional Cartesian GRE sequence and a density-adapted 3D radial readout sequence with cuboid field-of-view (DA-3D-RAD-C). We calibrated the 23Na MR signal using reference tubes either with or without agarose and subsequently performed a relaxation correction. Additionally, we employed a six-echo 1H GRE sequence and a multi-echo spin-echo sequence to calculate proton density fat fraction (PDFF) and water T2. Paired Wilcoxon signed-rank test, Cohen dz for paired samples, and Spearman correlation were used.Relaxation correction effectively reduced the differences in muscle aTSC between the two acquisition and calibration methods (DA-3D-RAD-C using NaCl/agarose references: 20.05 versus 19.14 mM; dz = 0.395; Cartesian GRE using NaCl/agarose references: 19.50 versus 18.82 mM; dz = 0.427). Both aTSC of the DA-3D-RAD-C and Cartesian GRE acquisitions showed a small but significant correlation with PDFF as well as with water T2.Different 23Na MRI acquisition and calibration approaches affect aTSC values. Applying relaxation correction is advised to minimize the impact of sequence parameters on quantification, and considering additional fat correction is advisable for patients with increased fat fractions.This study highlights relaxation correction's role in improving sodium MRI accuracy, paving the way for better disease assessment and comparability of measured sodium signal in patients.• Differences in MRI acquisition methods hamper the comparability of sodium MRI measurements. • Measured sodium values depend on used MRI sequences and calibration method. • Relaxation correction during postprocessing mitigates these discrepancies. • Thus, relaxation correction enhances accuracy of sodium MRI, aiding its clinical use.
KW  - Humans
KW  - Middle Aged
KW  - Muscle, Skeletal: diagnostic imaging
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Female
KW  - Retrospective Studies
KW  - Sodium
KW  - Sodium Isotopes
KW  - Aged
KW  - Adult
KW  - Imaging, Three-Dimensional: methods
KW  - Calibration (Other)
KW  - Magnetic resonance imaging (Other)
KW  - Muscle (skeletal) (Other)
KW  - Sodium (Other)
KW  - Volunteers (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38773044
DO  - DOI:10.1186/s41747-024-00461-1
UR  - https://inrepo02.dkfz.de/record/290353
ER  -