%0 Journal Article
%A Fellhofer-Hofer, Johanna
%A Franz, Clemens
%A Vey, Johannes A
%A Kahlert, Christoph
%A Kalkum, Eva
%A Mehrabi, Arianeb
%A Halama, Niels
%A Probst, Pascal
%A Klupp, Fee
%T Chemokines as Prognostic Factor in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis.
%J International journal of molecular sciences
%V 25
%N 10
%@ 1422-0067
%C Basel
%I Molecular Diversity Preservation International
%M DKFZ-2024-01111
%P 5374
%D 2024
%Z HI-TRON
%X Chemokines orchestrate many aspects of tumorigenic processes such as angiogenesis, apoptosis and metastatic spread, and related receptors are expressed on tumor cells as well as on inflammatory cells (e.g., tumor-infiltrating T cells, TILs) in the tumor microenvironment. Expressional changes of chemokines and their receptors in solid cancers are common and well known, especially in affecting colorectal cancer patient outcomes. Therefore, the aim of this current systematic review and meta-analysis was to classify chemokines as a prognostic biomarker in colorectal cancer patients. A systematic literature search was conducted in PubMed, CENTRAL and Web of Science. Information on the chemokine expression of 25 chemokines in colorectal cancer tissue and survival data of the patients were investigated. The hazard ratio of overall survival and disease-free survival with chemokine expression was examined. The risk of bias was analyzed using Quality in Prognosis Studies. Random effects meta-analysis was performed to determine the impact on overall respectively disease survival. For this purpose, the pooled hazard ratios (HR) and their 95
%K Humans
%K Colorectal Neoplasms: pathology
%K Colorectal Neoplasms: metabolism
%K Colorectal Neoplasms: mortality
%K Prognosis
%K Biomarkers, Tumor: metabolism
%K Chemokines: metabolism
%K Receptors, CXCR4: metabolism
%K Disease-Free Survival
%K CXCR4 expression (Other)
%K chemokine (Other)
%K colorectal cancer (Other)
%K outcome (Other)
%K survival (Other)
%K Biomarkers, Tumor (NLM Chemicals)
%K Chemokines (NLM Chemicals)
%K Receptors, CXCR4 (NLM Chemicals)
%K CXCR4 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38791414
%2 pmc:PMC11121014
%R 10.3390/ijms25105374
%U https://inrepo02.dkfz.de/record/290484