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@ARTICLE{FellhoferHofer:290484,
      author       = {J. Fellhofer-Hofer and C. Franz and J. A. Vey and C.
                      Kahlert and E. Kalkum and A. Mehrabi and N. Halama$^*$ and
                      P. Probst and F. Klupp},
      title        = {{C}hemokines as {P}rognostic {F}actor in {C}olorectal
                      {C}ancer {P}atients: {A} {S}ystematic {R}eview and
                      {M}eta-{A}nalysis.},
      journal      = {International journal of molecular sciences},
      volume       = {25},
      number       = {10},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2024-01111},
      pages        = {5374},
      year         = {2024},
      note         = {HI-TRON},
      abstract     = {Chemokines orchestrate many aspects of tumorigenic
                      processes such as angiogenesis, apoptosis and metastatic
                      spread, and related receptors are expressed on tumor cells
                      as well as on inflammatory cells (e.g., tumor-infiltrating T
                      cells, TILs) in the tumor microenvironment. Expressional
                      changes of chemokines and their receptors in solid cancers
                      are common and well known, especially in affecting
                      colorectal cancer patient outcomes. Therefore, the aim of
                      this current systematic review and meta-analysis was to
                      classify chemokines as a prognostic biomarker in colorectal
                      cancer patients. A systematic literature search was
                      conducted in PubMed, CENTRAL and Web of Science. Information
                      on the chemokine expression of 25 chemokines in colorectal
                      cancer tissue and survival data of the patients were
                      investigated. The hazard ratio of overall survival and
                      disease-free survival with chemokine expression was
                      examined. The risk of bias was analyzed using Quality in
                      Prognosis Studies. Random effects meta-analysis was
                      performed to determine the impact on overall respectively
                      disease survival. For this purpose, the pooled hazard ratios
                      (HR) and their $95\%$ confidence intervals (CI) were used
                      for calculation. Twenty-five chemokines were included, and
                      the search revealed 5556 publications. A total of thirty-one
                      publications were included in this systematic review and
                      meta-analysis. Overexpression of chemokine receptor CXCR4
                      was associated with both a significantly reduced overall
                      survival (HR = 2.70, $95\%-CI:$ 1.57 to 4.66, p = 0.0003) as
                      well as disease-free survival (HR = 2.68, $95\%-CI:$ 1.41 to
                      5.08, p = 0.0026). All other chemokines showed either
                      heterogeneous results or few studies were available. The
                      overall risk of bias for CXCR4 was rated low. At the current
                      level of evidence, this study demonstrates that CXCR4
                      overexpression in patients with colorectal cancer is
                      associated with a significantly diminished overall as well
                      as disease-free survival. Summed up, this systematic review
                      and meta-analysis reveals CXCR4 as a promising prognostic
                      biomarker. Nevertheless, more evidence is needed to evaluate
                      CXCR4 and its antagonists serving as new therapeutic
                      targets.},
      subtyp        = {Review Article},
      keywords     = {Humans / Colorectal Neoplasms: pathology / Colorectal
                      Neoplasms: metabolism / Colorectal Neoplasms: mortality /
                      Prognosis / Biomarkers, Tumor: metabolism / Chemokines:
                      metabolism / Receptors, CXCR4: metabolism / Disease-Free
                      Survival / CXCR4 expression (Other) / chemokine (Other) /
                      colorectal cancer (Other) / outcome (Other) / survival
                      (Other) / Biomarkers, Tumor (NLM Chemicals) / Chemokines
                      (NLM Chemicals) / Receptors, CXCR4 (NLM Chemicals) / CXCR4
                      protein, human (NLM Chemicals)},
      cin          = {D196},
      ddc          = {540},
      cid          = {I:(DE-He78)D196-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38791414},
      pmc          = {pmc:PMC11121014},
      doi          = {10.3390/ijms25105374},
      url          = {https://inrepo02.dkfz.de/record/290484},
}