000290551 001__ 290551
000290551 005__ 20241212140320.0
000290551 0247_ $$2doi$$a10.1126/sciadv.adk3121
000290551 0247_ $$2pmid$$apmid:38809988
000290551 0247_ $$2pmc$$apmc:PMC11135391
000290551 0247_ $$2altmetric$$aaltmetric:163934273
000290551 037__ $$aDKFZ-2024-01155
000290551 041__ $$aEnglish
000290551 082__ $$a500
000290551 1001_ $$00000-0002-8813-0816$$aDrew, David A$$b0
000290551 245__ $$aTwo genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.
000290551 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2024
000290551 3367_ $$2DRIVER$$aarticle
000290551 3367_ $$2DataCite$$aOutput Types/Journal article
000290551 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1734008575_30944
000290551 3367_ $$2BibTeX$$aARTICLE
000290551 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000290551 3367_ $$00$$2EndNote$$aJournal Article
000290551 520__ $$aRegular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit rs72833769), which has evidence of influencing expression of TBC1D7 (a subunit of the TSC1-TSC2 complex, a key regulator of MTOR activity), and variants in 5p13.1 (top hit rs350047), which is associated with expression of PTGER4 (codes a cell surface receptor directly involved in the mode of action of aspirin). Genetic variants with functional impact may modulate the chemopreventive effect of regular aspirin use, and our study identifies putative previously unidentified targets for additional mechanistic interrogation.
000290551 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000290551 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000290551 650_7 $$2NLM Chemicals$$aAnti-Inflammatory Agents, Non-Steroidal
000290551 650_7 $$0R16CO5Y76E$$2NLM Chemicals$$aAspirin
000290551 650_7 $$2NLM Chemicals$$aReceptors, Prostaglandin E, EP4 Subtype
000290551 650_7 $$2NLM Chemicals$$aPTGER4 protein, human
000290551 650_2 $$2MeSH$$aHumans
000290551 650_2 $$2MeSH$$aColorectal Neoplasms: genetics
000290551 650_2 $$2MeSH$$aColorectal Neoplasms: drug therapy
000290551 650_2 $$2MeSH$$aAnti-Inflammatory Agents, Non-Steroidal: pharmacology
000290551 650_2 $$2MeSH$$aGenome-Wide Association Study
000290551 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000290551 650_2 $$2MeSH$$aAspirin: pharmacology
000290551 650_2 $$2MeSH$$aReceptors, Prostaglandin E, EP4 Subtype: genetics
000290551 650_2 $$2MeSH$$aReceptors, Prostaglandin E, EP4 Subtype: metabolism
000290551 650_2 $$2MeSH$$aMale
000290551 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000290551 650_2 $$2MeSH$$aFemale
000290551 650_2 $$2MeSH$$aCase-Control Studies
000290551 650_2 $$2MeSH$$aMiddle Aged
000290551 650_2 $$2MeSH$$aGenetic Loci
000290551 650_2 $$2MeSH$$aAged
000290551 7001_ $$aKim, Andre E$$b1
000290551 7001_ $$00000-0001-8644-614X$$aLin, Yi$$b2
000290551 7001_ $$aQu, Conghui$$b3
000290551 7001_ $$00000-0003-1478-9965$$aMorrison, John$$b4
000290551 7001_ $$00000-0002-0692-2570$$aLewinger, Juan Pablo$$b5
000290551 7001_ $$aKawaguchi, Eric$$b6
000290551 7001_ $$00000-0001-8372-1863$$aWang, Jun$$b7
000290551 7001_ $$aFu, Yubo$$b8
000290551 7001_ $$00000-0002-9976-0784$$aZemlianskaia, Natalia$$b9
000290551 7001_ $$aDíez-Obrero, Virginia$$b10
000290551 7001_ $$00000-0002-8713-4583$$aBien, Stephanie A$$b11
000290551 7001_ $$00000-0003-1678-9328$$aDimou, Niki$$b12
000290551 7001_ $$aAlbanes, Demetrius$$b13
000290551 7001_ $$aBaurley, James W$$b14
000290551 7001_ $$aWu, Anna H$$b15
000290551 7001_ $$00000-0003-2225-6675$$aBuchanan, Daniel D$$b16
000290551 7001_ $$00000-0001-5439-1500$$aPotter, John D$$b17
000290551 7001_ $$00000-0003-2849-5757$$aPrentice, Ross L$$b18
000290551 7001_ $$00000-0001-8540-6891$$aHarlid, Sophia$$b19
000290551 7001_ $$0P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aArndt, Volker$$b20$$udkfz
000290551 7001_ $$aBarry, Elizabeth L$$b21
000290551 7001_ $$aBerndt, Sonja I$$b22
000290551 7001_ $$00000-0003-1489-5506$$aBouras, Emmanouil$$b23
000290551 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b24$$udkfz
000290551 7001_ $$aBudiarto, Arif$$b25
000290551 7001_ $$aBurnett-Hartman, Andrea$$b26
000290551 7001_ $$aCampbell, Peter T$$b27
000290551 7001_ $$00000-0002-2925-734X$$aCarreras-Torres, Robert$$b28
000290551 7001_ $$00000-0003-1584-5551$$aCasey, Graham$$b29
000290551 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b30$$udkfz
000290551 7001_ $$aConti, David V$$b31
000290551 7001_ $$00000-0001-5943-4397$$aDevall, Matthew A M$$b32
000290551 7001_ $$aFigueiredo, Jane C$$b33
000290551 7001_ $$00000-0001-8656-7822$$aGruber, Stephen B$$b34
000290551 7001_ $$00000-0002-9795-1528$$aGsur, Andrea$$b35
000290551 7001_ $$00000-0001-5472-6761$$aGunter, Marc J$$b36
000290551 7001_ $$00000-0002-4173-7530$$aHarrison, Tabitha A$$b37
000290551 7001_ $$aHidaka, Akihisa$$b38
000290551 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b39$$udkfz
000290551 7001_ $$00000-0001-6027-9806$$aHuyghe, Jeroen R$$b40
000290551 7001_ $$00000-0002-8964-6160$$aJenkins, Mark A$$b41
000290551 7001_ $$00000-0001-5165-5769$$aJordahl, Kristina M$$b42
000290551 7001_ $$00000-0003-3084-2287$$aKundaje, Anshul$$b43
000290551 7001_ $$aLe Marchand, Loic$$b44
000290551 7001_ $$aLi, Li$$b45
000290551 7001_ $$00000-0001-8060-547X$$aLynch, Brigid M$$b46
000290551 7001_ $$aMurphy, Neil$$b47
000290551 7001_ $$00000-0001-9914-7851$$aNassir, Rami$$b48
000290551 7001_ $$aNewcomb, Polly A$$b49
000290551 7001_ $$00000-0003-1471-5608$$aNewton, Christina C$$b50
000290551 7001_ $$aObón-Santacana, Mireia$$b51
000290551 7001_ $$00000-0002-3909-2323$$aOgino, Shuji$$b52
000290551 7001_ $$aOse, Jennifer$$b53
000290551 7001_ $$00000-0002-2692-221X$$aPai, Rish K$$b54
000290551 7001_ $$00000-0002-6534-335X$$aPalmer, Julie R$$b55
000290551 7001_ $$aPapadimitriou, Nikos$$b56
000290551 7001_ $$00000-0002-7404-9005$$aPardamean, Bens$$b57
000290551 7001_ $$00000-0002-0127-9790$$aPellatt, Andrew J$$b58
000290551 7001_ $$00000-0003-3645-3960$$aPeoples, Anita R$$b59
000290551 7001_ $$00000-0003-3676-8954$$aPlatz, Elizabeth A$$b60
000290551 7001_ $$00000-0002-8512-068X$$aRennert, Gad$$b61
000290551 7001_ $$00000-0002-0339-5824$$aRuiz-Narvaez, Edward$$b62
000290551 7001_ $$00000-0002-0900-5735$$aSakoda, Lori C$$b63
000290551 7001_ $$aScacheri, Peter C$$b64
000290551 7001_ $$00000-0001-5931-1194$$aSchmit, Stephanie L$$b65
000290551 7001_ $$00000-0001-7153-2766$$aSchoen, Robert E$$b66
000290551 7001_ $$aStern, Mariana C$$b67
000290551 7001_ $$00000-0001-6150-960X$$aSu, Yu-Ru$$b68
000290551 7001_ $$aThomas, Duncan C$$b69
000290551 7001_ $$aTian, Yu$$b70
000290551 7001_ $$00000-0002-8452-8472$$aTsilidis, Konstantinos K$$b71
000290551 7001_ $$00000-0001-7641-059X$$aUlrich, Cornelia M$$b72
000290551 7001_ $$00000-0001-5449-6230$$aUm, Caroline Y$$b73
000290551 7001_ $$00000-0001-8367-2352$$avan Duijnhoven, Fränzel J B$$b74
000290551 7001_ $$00000-0002-9692-101X$$aVan Guelpen, Bethany$$b75
000290551 7001_ $$aWhite, Emily$$b76
000290551 7001_ $$00000-0001-8168-4712$$aHsu, Li$$b77
000290551 7001_ $$00000-0002-2818-5487$$aMoreno, Victor$$b78
000290551 7001_ $$00000-0001-5666-9318$$aPeters, Ulrike$$b79
000290551 7001_ $$00000-0001-7284-6767$$aChan, Andrew T$$b80
000290551 7001_ $$00000-0002-6626-9091$$aGauderman, W James$$b81
000290551 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.adk3121$$gVol. 10, no. 22, p. eadk3121$$n22$$peadk3121$$tScience advances$$v10$$x2375-2548$$y2024
000290551 909CO $$ooai:inrepo02.dkfz.de:290551$$pVDB
000290551 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000290551 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000290551 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b30$$kDKFZ
000290551 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b39$$kDKFZ
000290551 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000290551 9141_ $$y2024
000290551 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI ADV : 2022$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-09-20T13:50:30Z
000290551 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-09-20T13:50:30Z
000290551 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2021-09-20T13:50:30Z
000290551 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bSCI ADV : 2022$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-28
000290551 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-28
000290551 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000290551 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000290551 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000290551 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x3
000290551 9201_ $$0I:(DE-He78)C071-20160331$$kC071$$lC071 Cancer Survivorship$$x4
000290551 980__ $$ajournal
000290551 980__ $$aVDB
000290551 980__ $$aI:(DE-He78)C070-20160331
000290551 980__ $$aI:(DE-He78)C120-20160331
000290551 980__ $$aI:(DE-He78)HD01-20160331
000290551 980__ $$aI:(DE-He78)C020-20160331
000290551 980__ $$aI:(DE-He78)C071-20160331
000290551 980__ $$aUNRESTRICTED