Home > Publications database > Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer. > print

001     290551
005     20241212140320.0
024 7 _ |a 10.1126/sciadv.adk3121
|2 doi
024 7 _ |a pmid:38809988
|2 pmid
024 7 _ |a pmc:PMC11135391
|2 pmc
024 7 _ |a altmetric:163934273
|2 altmetric
037 _ _ |a DKFZ-2024-01155
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Drew, David A
|0 0000-0002-8813-0816
|b 0
245 _ _ |a Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.
260 _ _ |a Washington, DC [u.a.]
|c 2024
|b Assoc.
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1734008575_30944
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit rs72833769), which has evidence of influencing expression of TBC1D7 (a subunit of the TSC1-TSC2 complex, a key regulator of MTOR activity), and variants in 5p13.1 (top hit rs350047), which is associated with expression of PTGER4 (codes a cell surface receptor directly involved in the mode of action of aspirin). Genetic variants with functional impact may modulate the chemopreventive effect of regular aspirin use, and our study identifies putative previously unidentified targets for additional mechanistic interrogation.
536 _ _ |a 313 - Krebsrisikofaktoren und Prävention (POF4-313)
|0 G:(DE-HGF)POF4-313
|c POF4-313
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
650 _ 7 |a Anti-Inflammatory Agents, Non-Steroidal
|2 NLM Chemicals
650 _ 7 |a Aspirin
|0 R16CO5Y76E
|2 NLM Chemicals
650 _ 7 |a Receptors, Prostaglandin E, EP4 Subtype
|2 NLM Chemicals
650 _ 7 |a PTGER4 protein, human
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Colorectal Neoplasms: genetics
|2 MeSH
650 _ 2 |a Colorectal Neoplasms: drug therapy
|2 MeSH
650 _ 2 |a Anti-Inflammatory Agents, Non-Steroidal: pharmacology
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide
|2 MeSH
650 _ 2 |a Aspirin: pharmacology
|2 MeSH
650 _ 2 |a Receptors, Prostaglandin E, EP4 Subtype: genetics
|2 MeSH
650 _ 2 |a Receptors, Prostaglandin E, EP4 Subtype: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Genetic Predisposition to Disease
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Case-Control Studies
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Genetic Loci
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
700 1 _ |a Kim, Andre E
|b 1
700 1 _ |a Lin, Yi
|0 0000-0001-8644-614X
|b 2
700 1 _ |a Qu, Conghui
|b 3
700 1 _ |a Morrison, John
|0 0000-0003-1478-9965
|b 4
700 1 _ |a Lewinger, Juan Pablo
|0 0000-0002-0692-2570
|b 5
700 1 _ |a Kawaguchi, Eric
|b 6
700 1 _ |a Wang, Jun
|0 0000-0001-8372-1863
|b 7
700 1 _ |a Fu, Yubo
|b 8
700 1 _ |a Zemlianskaia, Natalia
|0 0000-0002-9976-0784
|b 9
700 1 _ |a Díez-Obrero, Virginia
|b 10
700 1 _ |a Bien, Stephanie A
|0 0000-0002-8713-4583
|b 11
700 1 _ |a Dimou, Niki
|0 0000-0003-1678-9328
|b 12
700 1 _ |a Albanes, Demetrius
|b 13
700 1 _ |a Baurley, James W
|b 14
700 1 _ |a Wu, Anna H
|b 15
700 1 _ |a Buchanan, Daniel D
|0 0000-0003-2225-6675
|b 16
700 1 _ |a Potter, John D
|0 0000-0001-5439-1500
|b 17
700 1 _ |a Prentice, Ross L
|0 0000-0003-2849-5757
|b 18
700 1 _ |a Harlid, Sophia
|0 0000-0001-8540-6891
|b 19
700 1 _ |a Arndt, Volker
|0 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0
|b 20
|u dkfz
700 1 _ |a Barry, Elizabeth L
|b 21
700 1 _ |a Berndt, Sonja I
|b 22
700 1 _ |a Bouras, Emmanouil
|0 0000-0003-1489-5506
|b 23
700 1 _ |a Brenner, Hermann
|0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2
|b 24
|u dkfz
700 1 _ |a Budiarto, Arif
|b 25
700 1 _ |a Burnett-Hartman, Andrea
|b 26
700 1 _ |a Campbell, Peter T
|b 27
700 1 _ |a Carreras-Torres, Robert
|0 0000-0002-2925-734X
|b 28
700 1 _ |a Casey, Graham
|0 0000-0003-1584-5551
|b 29
700 1 _ |a Chang-Claude, Jenny
|0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
|b 30
|u dkfz
700 1 _ |a Conti, David V
|b 31
700 1 _ |a Devall, Matthew A M
|0 0000-0001-5943-4397
|b 32
700 1 _ |a Figueiredo, Jane C
|b 33
700 1 _ |a Gruber, Stephen B
|0 0000-0001-8656-7822
|b 34
700 1 _ |a Gsur, Andrea
|0 0000-0002-9795-1528
|b 35
700 1 _ |a Gunter, Marc J
|0 0000-0001-5472-6761
|b 36
700 1 _ |a Harrison, Tabitha A
|0 0000-0002-4173-7530
|b 37
700 1 _ |a Hidaka, Akihisa
|b 38
700 1 _ |a Hoffmeister, Michael
|0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f
|b 39
|u dkfz
700 1 _ |a Huyghe, Jeroen R
|0 0000-0001-6027-9806
|b 40
700 1 _ |a Jenkins, Mark A
|0 0000-0002-8964-6160
|b 41
700 1 _ |a Jordahl, Kristina M
|0 0000-0001-5165-5769
|b 42
700 1 _ |a Kundaje, Anshul
|0 0000-0003-3084-2287
|b 43
700 1 _ |a Le Marchand, Loic
|b 44
700 1 _ |a Li, Li
|b 45
700 1 _ |a Lynch, Brigid M
|0 0000-0001-8060-547X
|b 46
700 1 _ |a Murphy, Neil
|b 47
700 1 _ |a Nassir, Rami
|0 0000-0001-9914-7851
|b 48
700 1 _ |a Newcomb, Polly A
|b 49
700 1 _ |a Newton, Christina C
|0 0000-0003-1471-5608
|b 50
700 1 _ |a Obón-Santacana, Mireia
|b 51
700 1 _ |a Ogino, Shuji
|0 0000-0002-3909-2323
|b 52
700 1 _ |a Ose, Jennifer
|b 53
700 1 _ |a Pai, Rish K
|0 0000-0002-2692-221X
|b 54
700 1 _ |a Palmer, Julie R
|0 0000-0002-6534-335X
|b 55
700 1 _ |a Papadimitriou, Nikos
|b 56
700 1 _ |a Pardamean, Bens
|0 0000-0002-7404-9005
|b 57
700 1 _ |a Pellatt, Andrew J
|0 0000-0002-0127-9790
|b 58
700 1 _ |a Peoples, Anita R
|0 0000-0003-3645-3960
|b 59
700 1 _ |a Platz, Elizabeth A
|0 0000-0003-3676-8954
|b 60
700 1 _ |a Rennert, Gad
|0 0000-0002-8512-068X
|b 61
700 1 _ |a Ruiz-Narvaez, Edward
|0 0000-0002-0339-5824
|b 62
700 1 _ |a Sakoda, Lori C
|0 0000-0002-0900-5735
|b 63
700 1 _ |a Scacheri, Peter C
|b 64
700 1 _ |a Schmit, Stephanie L
|0 0000-0001-5931-1194
|b 65
700 1 _ |a Schoen, Robert E
|0 0000-0001-7153-2766
|b 66
700 1 _ |a Stern, Mariana C
|b 67
700 1 _ |a Su, Yu-Ru
|0 0000-0001-6150-960X
|b 68
700 1 _ |a Thomas, Duncan C
|b 69
700 1 _ |a Tian, Yu
|b 70
700 1 _ |a Tsilidis, Konstantinos K
|0 0000-0002-8452-8472
|b 71
700 1 _ |a Ulrich, Cornelia M
|0 0000-0001-7641-059X
|b 72
700 1 _ |a Um, Caroline Y
|0 0000-0001-5449-6230
|b 73
700 1 _ |a van Duijnhoven, Fränzel J B
|0 0000-0001-8367-2352
|b 74
700 1 _ |a Van Guelpen, Bethany
|0 0000-0002-9692-101X
|b 75
700 1 _ |a White, Emily
|b 76
700 1 _ |a Hsu, Li
|0 0000-0001-8168-4712
|b 77
700 1 _ |a Moreno, Victor
|0 0000-0002-2818-5487
|b 78
700 1 _ |a Peters, Ulrike
|0 0000-0001-5666-9318
|b 79
700 1 _ |a Chan, Andrew T
|0 0000-0001-7284-6767
|b 80
700 1 _ |a Gauderman, W James
|0 0000-0002-6626-9091
|b 81
773 _ _ |a 10.1126/sciadv.adk3121
|g Vol. 10, no. 22, p. eadk3121
|0 PERI:(DE-600)2810933-8
|n 22
|p eadk3121
|t Science advances
|v 10
|y 2024
|x 2375-2548
909 C O |p VDB
|o oai:inrepo02.dkfz.de:290551
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 20
|6 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 24
|6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 30
|6 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 39
|6 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-313
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Krebsrisikofaktoren und Prävention
|x 0
914 1 _ |y 2024
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b SCI ADV : 2022
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2021-09-20T13:50:30Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2021-09-20T13:50:30Z
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Anonymous peer review
|d 2021-09-20T13:50:30Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-08-28
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-08-28
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2023-08-28
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
|d 2023-08-28
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b SCI ADV : 2022
|d 2023-08-28
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2023-08-28
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2023-08-28
920 1 _ |0 I:(DE-He78)C070-20160331
|k C070
|l C070 Klinische Epidemiologie und Alternf.
|x 0
920 1 _ |0 I:(DE-He78)C120-20160331
|k C120
|l Präventive Onkologie
|x 1
920 1 _ |0 I:(DE-He78)HD01-20160331
|k HD01
|l DKTK HD zentral
|x 2
920 1 _ |0 I:(DE-He78)C020-20160331
|k C020
|l C020 Epidemiologie von Krebs
|x 3
920 1 _ |0 I:(DE-He78)C071-20160331
|k C071
|l C071 Cancer Survivorship
|x 4
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)C070-20160331
980 _ _ |a I:(DE-He78)C120-20160331
980 _ _ |a I:(DE-He78)HD01-20160331
980 _ _ |a I:(DE-He78)C020-20160331
980 _ _ |a I:(DE-He78)C071-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21