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@ARTICLE{Luo:290587,
      author       = {X. Luo and X. Jiang and V. Schmitt and S. R. Kulkarni$^*$
                      and H. C. Tran and S. M. Kacprzak and F. Van Breusegem and
                      O. Van Aken and K. Vandepoele and I. De Clercq},
      title        = {{A}rabidopsis transcription factor {ANAC}102 predominantly
                      expresses a nuclear protein and acts as a negative regulator
                      of methyl viologen-induced oxidative stress responses},
      journal      = {The journal of experimental botany},
      volume       = {75},
      number       = {15},
      issn         = {0022-0957},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2024-01184},
      pages        = {4655-4670},
      year         = {2024},
      note         = {DKFZ-ZMBH Alliance / 2024 Aug 12;75(15):4655-4670},
      abstract     = {Plants, being sessile organisms, constantly need to respond
                      to environmental stresses, often leading to the accumulation
                      of reactive oxygen species (ROS). While ROS can be harmful,
                      they also act as messengers guiding plant growth and stress
                      responses. Because chloroplasts are sensitive to
                      environmental changes and are both a source and target of
                      ROS during stress conditions, they are important in
                      conveying environmental changes to the nucleus, where
                      acclimation responses are coordinated to maintain organellar
                      and overall cellular homeostasis. ANAC102 has previously
                      been established as a regulator of β-cyclocitral-mediated
                      chloroplast-to-nucleus signaling, protecting plants against
                      photooxidative stress. However, debates persist about where
                      ANAC102 is located - in chloroplasts or in the nucleus. Our
                      study, utilizing the genomic ANAC102 sequence driven by its
                      native promoter, establishes ANAC102 primarily as a nuclear
                      protein, lacking a complete N-terminal chloroplast-targeting
                      peptide. Moreover, our research reveals the sensitivity of
                      plants overexpressing ANAC102 to severe superoxide-induced
                      chloroplast oxidative stress. Transcriptome analysis
                      unraveled ANAC102's dual role in negatively and positively
                      regulating genome-wide transcriptional responses to
                      chloroplast oxidative stress. Through the integration of
                      published data and our own study, we constructed a
                      comprehensive transcriptional network, which suggests that
                      ANAC102 exerts direct and indirect control over
                      transcriptional responses through downstream transcription
                      factor networks, providing deeper insights into the
                      ANAC102-mediated regulatory landscape during oxidative
                      stress.},
      keywords     = {Arabidopsis (Other) / chloroplasts (Other) / gene
                      regulatory networks (Other) / oxidative stress (Other) /
                      retrograde signaling (Other) / transcription factors
                      (Other)},
      cin          = {A190},
      ddc          = {580},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38812358},
      doi          = {10.1093/jxb/erae235},
      url          = {https://inrepo02.dkfz.de/record/290587},
}