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@ARTICLE{Mynarek:290620,
      author       = {M. Mynarek and A. Rossius and A. Guiard and H. Ottensmeier
                      and K. von Hoff and D. Obrecht-Sturm and L. Bußenius and C.
                      Friedrich and A. O. von Bueren and N. U. Gerber and T.
                      Traunwieser and R.-D. Kortmann and M. Warmuth-Metz and B.
                      Bison and U.-W. Thomale and J. Krauss and T. Pietsch and S.
                      C. Clifford and S. M. Pfister$^*$ and D. Sturm$^*$ and F.
                      Sahm$^*$ and T. Tischler and S. Rutkowski},
      title        = {{R}isk factors for domain-specific neurocognitive outcome
                      in pediatric survivors of a brain tumor in the posterior
                      fossa - {R}esults of the {HIT} 2000 trial.},
      journal      = {Neuro-Oncology},
      volume       = {26},
      number       = {11},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2024-01206},
      pages        = {2113-2124},
      year         = {2024},
      note         = {2024 Nov 4;26(11):2113-2124},
      abstract     = {Neurocognition can be severely affected in pediatric brain
                      tumor survivors. We analyzed the association of cognitive
                      functioning with radiotherapy dose, postoperative cerebellar
                      mutism syndrome (pCMS), hydrocephalus, intraventricular
                      methotrexate (MTX) application, tumor localization and
                      biology in pediatric survivors of a posterior fossa
                      tumor.Subdomain-specific neurocognitive outcome data from
                      279 relapse-free survivors of the HIT-2000 trial (241
                      medulloblastoma and 38 infratentorial ependymoma) using the
                      Neuropsychological Basic Diagnostic (NBD) tool based on
                      Cattell-Horn-Carroll's model for intelligence were
                      analyzed.Cognitive performance 5.14 years (mean;
                      range=1.52-13.02) after diagnosis was significantly below
                      normal for all subtests. Processing speed and psychomotor
                      abilities were most affected. Influencing factors were
                      domain-specific: CSI-dose had strong impact on most
                      subtests. pCMS was associated with psychomotor abilities
                      (β=-0.25 to -0.16) and processing speed (β=-0.32).
                      Postoperative hydrocephalus correlated with crystallized
                      intelligence (β=-0.20) and short-term memory (β=-0.15),
                      age with crystallized intelligence (β=0.15) and psychomotor
                      abilities (β=-0.16 and β=-0.17). Scores for fluid
                      intelligence (β=-0.23), short-term memory (β=-0.17) and
                      visual processing (β=-0.25) declined, and scores for
                      selective attention improved (β=0.29) with time after
                      diagnosis.Dose of CSI was strongly associated with
                      neurocognitive outcome. Low psychomotor abilities and
                      processing speed both in patients treated with and without
                      CSI suggest a strong contribution of the tumor and its
                      surgery on these functions. Future research therefore should
                      analyze strategies to both reduce CSI-dose and toxicity
                      caused by other treatment modalities.},
      keywords     = {Infant (Other) / ependymoma (Other) / medulloblastoma
                      (Other) / neuropsychological late effects (Other) / quality
                      of survival (Other)},
      cin          = {B062 / HD01 / B300},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38835160},
      doi          = {10.1093/neuonc/noae092},
      url          = {https://inrepo02.dkfz.de/record/290620},
}