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000290623 1001_ $$aShiraishi, Ryo$$b0
000290623 245__ $$aCancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression.
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000290623 500__ $$a2024 Sep 9;59(17):2302-2319.e12
000290623 520__ $$aNormal cells coordinate proliferation and differentiation by precise tuning of gene expression based on the dynamic shifts of the epigenome throughout the developmental timeline. Although non-mutational epigenetic reprogramming is an emerging hallmark of cancer, the epigenomic shifts that occur during the transition from normal to malignant cells remain elusive. Here, we capture the epigenomic changes that occur during tumorigenesis in a prototypic embryonal brain tumor, medulloblastoma. By comparing the epigenomes of the different stages of transforming cells in mice, we identify nuclear factor I family of transcription factors, known to be cell fate determinants in development, as oncogenic regulators in the epigenomes of precancerous and cancerous cells. Furthermore, genetic and pharmacological inhibition of NFIB validated a crucial role of this transcription factor by disrupting the cancer epigenome in medulloblastoma. Thus, this study exemplifies how epigenomic changes contribute to tumorigenesis via non-mutational mechanisms involving developmental transcription factors.
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000290623 650_7 $$2Other$$abrain tumor
000290623 650_7 $$2Other$$acerebellar granule cell
000290623 650_7 $$2Other$$acerebellum
000290623 650_7 $$2Other$$aepigenome
000290623 650_7 $$2Other$$amedulloblastoma
000290623 650_7 $$2Other$$amouse model
000290623 650_7 $$2Other$$anuclear factor I
000290623 7001_ $$aCancila, Gabriele$$b1
000290623 7001_ $$aKumegawa, Kohei$$b2
000290623 7001_ $$aTorrejon, Jacob$$b3
000290623 7001_ $$aBasili, Irene$$b4
000290623 7001_ $$aBernardi, Flavia$$b5
000290623 7001_ $$0P:(DE-HGF)0$$aSilva, Patricia Benites Goncalves da$$b6
000290623 7001_ $$aWang, Wanchen$$b7
000290623 7001_ $$aChapman, Owen$$b8
000290623 7001_ $$aYang, Liying$$b9
000290623 7001_ $$aJami, Maki$$b10
000290623 7001_ $$aNishitani, Kayo$$b11
000290623 7001_ $$aArai, Yukimi$$b12
000290623 7001_ $$aXiao, Zhize$$b13
000290623 7001_ $$aYu, Hua$$b14
000290623 7001_ $$aLo Re, Valentina$$b15
000290623 7001_ $$aMarsaud, Véronique$$b16
000290623 7001_ $$aTalbot, Julie$$b17
000290623 7001_ $$aLombard, Bérangère$$b18
000290623 7001_ $$aLoew, Damarys$$b19
000290623 7001_ $$aJingu, Maho$$b20
000290623 7001_ $$0P:(DE-He78)34b3639de467b2c700920d7cbc3d2110$$aOkonechnikov, Konstantin$$b21$$udkfz
000290623 7001_ $$aSone, Masaki$$b22
000290623 7001_ $$aMotohashi, Norio$$b23
000290623 7001_ $$aAoki, Yoshitsugu$$b24
000290623 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b25$$udkfz
000290623 7001_ $$aChavez, Lukas$$b26
000290623 7001_ $$aHoshino, Mikio$$b27
000290623 7001_ $$aMaruyama, Reo$$b28
000290623 7001_ $$aAyrault, Olivier$$b29
000290623 7001_ $$aKawauchi, Daisuke$$b30
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