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@ARTICLE{Willnow:290853,
      author       = {P. Willnow$^*$ and A. Teleman$^*$},
      title        = {{N}uclear position and local acetyl-{C}o{A} production
                      regulate chromatin state.},
      journal      = {Nature},
      volume       = {630},
      number       = {8016},
      issn         = {0028-0836},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2024-01210},
      pages        = {466-474},
      year         = {2024},
      note         = {#EA:B140#LA:B140# / 2024 Jun;630(8016):466-474},
      abstract     = {Histone acetylation regulates gene expression, cell
                      function and cell fate1. Here we study the pattern of
                      histone acetylation in the epithelial tissue of the
                      Drosophila wing disc. H3K18ac, H4K8ac and total lysine
                      acetylation are increased in the outer rim of the disc. This
                      acetylation pattern is controlled by nuclear position,
                      whereby nuclei continuously move from apical to basal
                      locations within the epithelium and exhibit high levels of
                      H3K18ac when they are in proximity to the tissue surface.
                      These surface nuclei have increased levels of acetyl-CoA
                      synthase, which generates the acetyl-CoA for histone
                      acetylation. The carbon source for histone acetylation in
                      the rim is fatty acid β-oxidation, which is also increased
                      in the rim. Inhibition of fatty acid β-oxidation causes
                      H3K18ac levels to decrease in the genomic proximity of genes
                      involved in disc development. In summary, there is a
                      physical mark of the outer rim of the wing and other
                      imaginal epithelia in Drosophila that affects gene
                      expression.},
      cin          = {B140},
      ddc          = {500},
      cid          = {I:(DE-He78)B140-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38839952},
      doi          = {10.1038/s41586-024-07471-4},
      url          = {https://inrepo02.dkfz.de/record/290853},
}