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000291060 1001_ $$00000-0002-5196-3283$$aPaul, Cinara$$b0
000291060 245__ $$aGender-specific factors associated with case complexity in middle-aged and older adults-Evidence from a large population-based study.
000291060 260__ $$aChichester [u.a.]$$bWiley$$c2024
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000291060 520__ $$aTo investigate gender-specific factors associated with case complexity in a population-based sample of middle-aged and older adults using a holistic approach to complexity.Data were derived from the 8-year follow-up home visits of the ESTHER study-a German population-based study in middle-aged and older adults. Cross-sectional analyses were conducted for 2932 persons (aged 57-84). Complexity was assessed by the well-established INTERMED for the elderly interview, which uses a holistic approach to the definition of case complexity. The association between various bio-psycho-social variables and case complexity was analyzed using gender-specific logistic regression models, adjusted for sociodemographic factors (age, marital status, education).Prevalence of complexity was 8.3% with significantly higher prevalence in female (10.6%) compared to male (5.8%) participants (p < 0.001). Variables associated with increased odds for complexity in both, women and men were: being divorced (odds ratio [OR] women: 1.86, 95% CI 1.05-3.30; OR men: 3.19, 1.25-8.12), higher total somatic morbidity (women: 1.08, 1.04-1.12; men: 1.06, 1.02-1.11), higher depression severity (women: 1.34, 1.28-1.40; men: 1.35, 1.27-1.44), and higher loneliness scores (women: 1.19, 1.05-1.36; men: 1.23, 1.03-1.47). Women (but not men) with obesity (Body mass index [BMI] ≥30) had higher odds (1.79, 1.11-2.89) for being complex compared to those with a BMI <25. High oxidative stress measured by derivatives of reactive oxygen metabolites in serum was associated with 2.02 (1.09-3.74) higher odds for complexity only in men.This study provides epidemiological evidence on gender differences in prevalence and factors associated with case complexity in middle-aged and older adults. Moreover, this study adds to the holistic understanding of complexity by identifying novel variables linked to complexity among middle-aged and older individuals. These factors include loneliness for both genders, and high oxidative stress for men. These findings should be confirmed in future longitudinal studies.
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000291060 650_7 $$2Other$$abio‐psycho‐social
000291060 650_7 $$2Other$$acomplexity
000291060 650_7 $$2Other$$aloneliness
000291060 650_7 $$2Other$$aolder adults
000291060 650_7 $$2Other$$aoxidative stress
000291060 650_2 $$2MeSH$$aHumans
000291060 650_2 $$2MeSH$$aFemale
000291060 650_2 $$2MeSH$$aMale
000291060 650_2 $$2MeSH$$aAged
000291060 650_2 $$2MeSH$$aMiddle Aged
000291060 650_2 $$2MeSH$$aCross-Sectional Studies
000291060 650_2 $$2MeSH$$aAged, 80 and over
000291060 650_2 $$2MeSH$$aGermany: epidemiology
000291060 650_2 $$2MeSH$$aSex Factors
000291060 650_2 $$2MeSH$$aLogistic Models
000291060 650_2 $$2MeSH$$aPrevalence
000291060 650_2 $$2MeSH$$aRisk Factors
000291060 650_2 $$2MeSH$$aLoneliness: psychology
000291060 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b1$$udkfz
000291060 7001_ $$aHartmann, Mechthild$$b2
000291060 7001_ $$aFriederich, Hans-Christoph$$b3
000291060 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$udkfz
000291060 7001_ $$aWild, Beate$$b5
000291060 773__ $$0PERI:(DE-600)1500455-7$$a10.1002/gps.6113$$gVol. 39, no. 6, p. e6113$$n6$$pe6113$$tInternational journal of geriatric psychiatry$$v39$$x0885-6230$$y2024
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