000291069 001__ 291069
000291069 005__ 20250129163506.0
000291069 0247_ $$2doi$$a10.1093/bjd/ljae255
000291069 0247_ $$2pmid$$apmid:38878280
000291069 0247_ $$2ISSN$$a0366-2845
000291069 0247_ $$2ISSN$$a0007-0963
000291069 0247_ $$2ISSN$$a0366-077X
000291069 0247_ $$2ISSN$$a1365-2133
000291069 0247_ $$2altmetric$$aaltmetric:164591605
000291069 037__ $$aDKFZ-2024-01289
000291069 041__ $$aEnglish
000291069 082__ $$a610
000291069 1001_ $$0P:(DE-He78)93b84588571c05b85df1c0916f740e98$$aHasche, Daniel$$b0$$eFirst author$$udkfz
000291069 245__ $$aCytokeratin-17 expression is commonly observed in keratinocytic skin tumours and controls tissue homeostasis impacting HPV protein expression.
000291069 260__ $$aOxford$$bOxford University Press$$c2024
000291069 3367_ $$2DRIVER$$aarticle
000291069 3367_ $$2DataCite$$aOutput Types/Journal article
000291069 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1738136015_15069
000291069 3367_ $$2BibTeX$$aARTICLE
000291069 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000291069 3367_ $$00$$2EndNote$$aJournal Article
000291069 500__ $$a#EA:F030# / 2024 Nov 18;191(6):949-963
000291069 520__ $$aThe structured expression of several keratins in the skin is associated with differentiation status of the epidermal layers, whereas others are upregulated only during wound healing, in skin disorders and in cancers. One of these stress keratins, K17, is correlated with poor prognosis in various cancer types and its loss has been shown to decelerate tumour growth. K17 expression can also be detected in cutaneous squamous cell carcinomas (SCCs), where UV-irradiation and infection with cutaneous human papillomaviruses (HPVs) are important co-factors. It was previously reported that K17 is upregulated in papillomavirus (PV)-induced benign skin lesions in mice and induces an immunological status that is beneficial for tumour growth.In order to investigate whether K17 upregulation is induced by PVs, we analysed K17 levels in skin tumour specimens of different animal models and humans.Various immunofluorescence stainings were performed to identify K17 expression as well as levels of E-Cadherin, vimentin and CD271. Tissues were further analysed by PCRs, qPCRs and ELISA to control for PV activity. K17knockdown cells were generated and effects on viral life cycle were investigated by infection assays, qPCR and Western blotting.We could show that K17 is commonly expressed in skin tumours and that its presence is not directly linked to viral oncoprotein expression. Rather, K17 expression seems to be a marker of epithelial differentiation and its absence in tumour tissue is associated with an epithelial-to-mesenchymal transition. We further showed that the absence of K17 in skin tumours increases markers of cancer stem-like cells and negatively affects viral protein synthesis.Collectively, our data indicate that K17 expression is a common feature in skin tumourigenesis. While it is not primarily targeted by PV oncoproteins, our in vivo and in vitro data suggest that it is an important regulator of epithelial differentiation and thus may play a role in controlling viral protein synthesis.
000291069 536__ $$0G:(DE-HGF)POF4-314$$a314 - Immunologie und Krebs (POF4-314)$$cPOF4-314$$fPOF IV$$x0
000291069 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000291069 7001_ $$aHufbauer, Martin$$b1
000291069 7001_ $$0P:(DE-He78)810ef819c7d86928b119192db5730fc7$$aBraspenning-Wesch, Ilona$$b2$$udkfz
000291069 7001_ $$0P:(DE-He78)fd869847d6731bf306dce72ed1ef343b$$aStephan, Sonja$$b3$$udkfz
000291069 7001_ $$aSilling, Steffi$$b4
000291069 7001_ $$0P:(DE-He78)e8868a5fc184fe2e756d7e11ad1ac748$$aSchmidt, Gabriele$$b5$$udkfz
000291069 7001_ $$0P:(DE-He78)9ea61053e4bed51c6256fe19a0559868$$aKrieg, Stephan$$b6$$udkfz
000291069 7001_ $$00000-0003-2275-499X$$aKreuter, Alexander$$b7
000291069 7001_ $$aAkgül, Baki$$b8
000291069 773__ $$0PERI:(DE-600)2004086-6$$a10.1093/bjd/ljae255$$gp. ljae255$$n6$$p949-963$$tBritish journal of dermatology$$v191$$x0366-2845$$y2024
000291069 8767_ $$8SOA24LT006900$$92024-06-14$$d2024-11-14$$eAPC$$jZahlung erfolgt
000291069 909CO $$ooai:inrepo02.dkfz.de:291069$$pVDB$$popenCost$$pOpenAPC
000291069 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)93b84588571c05b85df1c0916f740e98$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000291069 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)810ef819c7d86928b119192db5730fc7$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000291069 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fd869847d6731bf306dce72ed1ef343b$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000291069 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e8868a5fc184fe2e756d7e11ad1ac748$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000291069 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)9ea61053e4bed51c6256fe19a0559868$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000291069 9131_ $$0G:(DE-HGF)POF4-314$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImmunologie und Krebs$$x0
000291069 9141_ $$y2024
000291069 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000291069 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000291069 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-23$$wger
000291069 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-08-23$$wger
000291069 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRIT J DERMATOL : 2022$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-23
000291069 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bBRIT J DERMATOL : 2022$$d2023-08-23
000291069 9201_ $$0I:(DE-He78)F030-20160331$$kF030$$lVirale Transformationsmechanismen$$x0
000291069 9201_ $$0I:(DE-He78)W210-20160331$$kW210$$lLichtmikroskopie$$x1
000291069 9201_ $$0I:(DE-He78)F190-20160331$$kF190$$lNWG Cell Plasticity and Epigenetic Remodeling$$x2
000291069 9200_ $$0I:(DE-He78)F030-20160331$$kF030$$lVirale Transformationsmechanismen$$x0
000291069 980__ $$ajournal
000291069 980__ $$aVDB
000291069 980__ $$aI:(DE-He78)F030-20160331
000291069 980__ $$aI:(DE-He78)W210-20160331
000291069 980__ $$aI:(DE-He78)F190-20160331
000291069 980__ $$aAPC
000291069 980__ $$aUNRESTRICTED
000291069 9801_ $$aAPC