%0 Journal Article
%A Adolph, Jonas E
%A Fleischhack, Gudrun
%A Tschirner, Sebastian
%A Rink, Lydia
%A Dittes, Christine
%A Mikasch, Ruth
%A Dammann, Philipp
%A Mynarek, Martin
%A Obrecht-Sturm, Denise
%A Rutkowski, Stefan
%A Bison, Brigitte
%A Warmuth-Metz, Monika
%A Pietsch, Torsten
%A Pfister, Stefan
%A Pajtler, Kristian
%A Milde, Till
%A Kortmann, Rolf-Dieter
%A Dietzsch, Stefan
%A Timmermann, Beate
%A Tippelt, Stephan
%T Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation.
%J Cancers
%V 16
%N 11
%@ 2072-6694
%C Basel
%I MDPI
%M DKFZ-2024-01307
%P 1955
%D 2024
%X Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects.For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2.A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months] and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8
%K medulloblastoma (Other)
%K radiotherapy (Other)
%K re-irradiation (Other)
%K recurrence (Other)
%K resection (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38893076
%2 pmc:PMC11171022
%R 10.3390/cancers16111955
%U https://inrepo02.dkfz.de/record/291102