TY  - JOUR
AU  - Adolph, Jonas E
AU  - Fleischhack, Gudrun
AU  - Tschirner, Sebastian
AU  - Rink, Lydia
AU  - Dittes, Christine
AU  - Mikasch, Ruth
AU  - Dammann, Philipp
AU  - Mynarek, Martin
AU  - Obrecht-Sturm, Denise
AU  - Rutkowski, Stefan
AU  - Bison, Brigitte
AU  - Warmuth-Metz, Monika
AU  - Pietsch, Torsten
AU  - Pfister, Stefan
AU  - Pajtler, Kristian
AU  - Milde, Till
AU  - Kortmann, Rolf-Dieter
AU  - Dietzsch, Stefan
AU  - Timmermann, Beate
AU  - Tippelt, Stephan
TI  - Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation.
JO  - Cancers
VL  - 16
IS  - 11
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2024-01307
SP  - 1955
PY  - 2024
AB  - Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects.For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2.A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months] and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8
KW  - medulloblastoma (Other)
KW  - radiotherapy (Other)
KW  - re-irradiation (Other)
KW  - recurrence (Other)
KW  - resection (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38893076
C2  - pmc:PMC11171022
DO  - DOI:10.3390/cancers16111955
UR  - https://inrepo02.dkfz.de/record/291102
ER  -