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@ARTICLE{Adolph:291102,
author = {J. E. Adolph and G. Fleischhack and S. Tschirner and L.
Rink and C. Dittes and R. Mikasch and P. Dammann and M.
Mynarek and D. Obrecht-Sturm and S. Rutkowski and B. Bison
and M. Warmuth-Metz and T. Pietsch and S. Pfister$^*$ and K.
Pajtler$^*$ and T. Milde$^*$ and R.-D. Kortmann and S.
Dietzsch and B. Timmermann and S. Tippelt},
collaboration = {G. G. HIT-Network},
title = {{R}adiotherapy for {R}ecurrent {M}edulloblastoma in
{C}hildren and {A}dolescents: {S}urvival after
{R}e-{I}rradiation and {F}irst-{T}ime {I}rradiation.},
journal = {Cancers},
volume = {16},
number = {11},
issn = {2072-6694},
address = {Basel},
publisher = {MDPI},
reportid = {DKFZ-2024-01307},
pages = {1955},
year = {2024},
abstract = {Radiotherapy (RT) involving craniospinal irradiation (CSI)
is important in the initial treatment of medulloblastoma. At
recurrence, the re-irradiation options are limited and
associated with severe side-effects.For pre-irradiated
patients, patients with re-irradiation (RT2) were matched by
sex, histology, time to recurrence, disease status and
treatment at recurrence to patients without RT2.A total of
42 pre-irradiated patients with RT2 were matched to 42
pre-irradiated controls without RT2. RT2 improved the median
PFS [21.0 (CI: 15.7-28.7) vs. 12.0 (CI: 8.1-21.0) months]
and OS [31.5 (CI: 27.6-64.8) vs. 20.0 (CI: 14.0-36.7)
months]. Concerning long-term survival after ten years, RT2
only lead to small improvements in OS $[8\%$ (CI: 1.4-45.3)
vs. $0\%].$ RT2 improved survival most without
(re)-resection [PFS: 17.5 (CI: 9.7-41.5) vs. 8.0 (CI:
6.6-12.2)/OS: 31.5 (CI: 27.6-NA) vs. 13.3 (CI: 8.1-20.1)
months]. In the RT-naïve patients, CSI at recurrence
improved their median PFS [25.0 (CI: 16.8-60.6) vs. 6.6 (CI:
1.5-NA) months] and OS [40.2 (CI: 18.7-NA) vs. 12.4 (CI:
4.4-NA) months].RT2 could improve the median survival in a
matched cohort but offered little benefit regarding
long-term survival. In RT-naïve patients, CSI greatly
improved their median and long-term survival.},
keywords = {medulloblastoma (Other) / radiotherapy (Other) /
re-irradiation (Other) / recurrence (Other) / resection
(Other)},
cin = {B062 / B310 / HD01},
ddc = {610},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)B310-20160331 /
I:(DE-He78)HD01-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:38893076},
pmc = {pmc:PMC11171022},
doi = {10.3390/cancers16111955},
url = {https://inrepo02.dkfz.de/record/291102},
}