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@ARTICLE{Mikolajczyk:291113,
      author       = {R. Mikolajczyk and S. Diexer and B. Klee and L. Pfrommer
                      and O. Purschke and J. Fricke and P. Ahnert and S. Gabrysch
                      and C. Gottschick and B. Bohn and H. Brenner$^*$ and C. Buck
                      and S. Castell and S. Gastell and K. H. Greiser$^*$ and V.
                      Harth and J.-K. Heise and B. Holleczek and R. Kaaks$^*$ and
                      T. Keil and L. Krist and M. Leitzmann and W. Lieb and C.
                      Meinke-Franze and K. B. Michels and I. M. Velásquez and N.
                      Obi and L. Panreck and A. Peters and T. Pischon and T.
                      Schikowski and B. Schmidt and M. Standl and A. Stang and H.
                      Völzke and A. Weber and H. Zeeb and A. Karch},
      title        = {{L}ikelihood of {P}ost-{COVID} {C}ondition in people with
                      hybrid immunity; data from the {G}erman {N}ational {C}ohort
                      ({NAKO}).},
      journal      = {Journal of infection},
      volume       = {89},
      number       = {2},
      issn         = {0163-4453},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01316},
      pages        = {106206},
      year         = {2024},
      note         = {2024 Jun 17;89(2):106206},
      abstract     = {The risk of Post-COVID-19 condition (PCC) under hybrid
                      immunity remains unclear.Using data from the German National
                      Cohort (NAKO Gesundheitsstudie), we investigated risk
                      factors for self-reported post-infection symptoms (any PCC
                      is defined as having at least one symptom, and high symptom
                      burden PCC as having nine or more symptoms).Sixty percent of
                      109,707 participants reported at least one previous
                      SARS-CoV-2 infection; $35\%$ reported having had any
                      symptoms 4-12 months after infection; among them $23\%$
                      reported nine or more symptoms. Individuals, who did not
                      develop PCC after their first infection, had a strongly
                      reduced risk for PCC after their second infection $(50\%)$
                      and a temporary risk reduction, which waned over nine months
                      after the preceding infection. The risk of developing PCC
                      strongly depended on the virus variant. Within variants,
                      there was no effect of the number of preceding vaccinations,
                      apart from a strong protection by the fourth vaccination
                      compared to three vaccinations for the Omicron variant (odds
                      ratio=0.52; $95\%$ confidence interval 0.45-0.61).Previous
                      infections without PCC and a fourth vaccination were
                      associated with a lower risk of PCC after a new infection,
                      indicating diminished risk under hybrid immunity. The two
                      components of risk reduction after a preceding infection
                      suggest different immunological mechanisms.},
      keywords     = {Hybrid Immunity (Other) / Post-COVID-19 condition (Other) /
                      Reinfection (Other) / SARS-CoV-2 (Other) / Vaccination
                      (Other)},
      cin          = {C070 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38897239},
      doi          = {10.1016/j.jinf.2024.106206},
      url          = {https://inrepo02.dkfz.de/record/291113},
}