%0 Journal Article
%A Yuan, Tanwei
%A Wankhede, Durgesh
%A Edelmann, Dominic
%A Kather, Jakob Nikolas
%A Tagscherer, Katrin E
%A Roth, Wilfried
%A Bewerunge-Hudler, Melanie
%A Brobeil, Alexander
%A Kloor, Matthias
%A Bläker, Hendrik
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Large-scale external validation and meta-analysis of gene methylation biomarkers in tumor tissue for colorectal cancer prognosis.
%J EBioMedicine
%V 105
%@ 2352-3964
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2024-01343
%P 105223
%D 2024
%Z #EA:C070#LA:C070#
%X DNA methylation biomarkers in colorectal cancer (CRC) tissue hold potential as prognostic indicators. However, individual studies have yielded heterogeneous results, and external validation is largely absent. We conducted a comprehensive external validation and meta-analysis of previously suggested gene methylation biomarkers for CRC prognosis.We performed a systematic search to identify relevant studies investigating gene methylation biomarkers for CRC prognosis until March 2024. Our external validation cohort with long-term follow-up included 2303 patients with CRC from 22 hospitals in southwest Germany. We used Cox regression analyses to assess associations between previously suggested gene methylation biomarkers and prognosis, adjusting for clinical variables. We calculated pooled hazard ratios (HRs) and their 95
%K Colorectal cancer (Other)
%K External validation (Other)
%K Gene methylation biomarkers (Other)
%K Meta-analysis (Other)
%K Prognosis (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38917511
%R 10.1016/j.ebiom.2024.105223
%U https://inrepo02.dkfz.de/record/291257