TY  - JOUR
AU  - Yuan, Tanwei
AU  - Wankhede, Durgesh
AU  - Edelmann, Dominic
AU  - Kather, Jakob Nikolas
AU  - Tagscherer, Katrin E
AU  - Roth, Wilfried
AU  - Bewerunge-Hudler, Melanie
AU  - Brobeil, Alexander
AU  - Kloor, Matthias
AU  - Bläker, Hendrik
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Large-scale external validation and meta-analysis of gene methylation biomarkers in tumor tissue for colorectal cancer prognosis.
JO  - EBioMedicine
VL  - 105
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-01343
SP  - 105223
PY  - 2024
N1  - #EA:C070#LA:C070#
AB  - DNA methylation biomarkers in colorectal cancer (CRC) tissue hold potential as prognostic indicators. However, individual studies have yielded heterogeneous results, and external validation is largely absent. We conducted a comprehensive external validation and meta-analysis of previously suggested gene methylation biomarkers for CRC prognosis.We performed a systematic search to identify relevant studies investigating gene methylation biomarkers for CRC prognosis until March 2024. Our external validation cohort with long-term follow-up included 2303 patients with CRC from 22 hospitals in southwest Germany. We used Cox regression analyses to assess associations between previously suggested gene methylation biomarkers and prognosis, adjusting for clinical variables. We calculated pooled hazard ratios (HRs) and their 95
KW  - Colorectal cancer (Other)
KW  - External validation (Other)
KW  - Gene methylation biomarkers (Other)
KW  - Meta-analysis (Other)
KW  - Prognosis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38917511
DO  - DOI:10.1016/j.ebiom.2024.105223
UR  - https://inrepo02.dkfz.de/record/291257
ER  -