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000291272 1001_ $$00000-0001-6216-9803$$aCorradi, Chiara$$b0
000291272 245__ $$aPotential association between PSCA rs2976395 functional variant and pancreatic cancer risk.
000291272 260__ $$aBognor Regis$$bWiley-Liss$$c2024
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000291272 500__ $$a#LA:C055# / 2024 Oct 15;155(8):1432-1442
000291272 520__ $$aCorrelated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10-5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association.
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000291272 650_7 $$2Other$$aDNA methylation
000291272 650_7 $$2Other$$apancreatic cancer
000291272 650_7 $$2Other$$arisk factors
000291272 650_7 $$2Other$$asingle‐nucleotide polymorphism
000291272 7001_ $$aLencioni, Giulia$$b1
000291272 7001_ $$aFelici, Alessio$$b2
000291272 7001_ $$00000-0002-7830-2178$$aRizzato, Cosmeri$$b3
000291272 7001_ $$aGentiluomo, Manuel$$b4
000291272 7001_ $$aErmini, Stefano$$b5
000291272 7001_ $$aArchibugi, Livia$$b6
000291272 7001_ $$aMickevicius, Antanas$$b7
000291272 7001_ $$aLucchesi, Maurizio$$b8
000291272 7001_ $$aMalecka-Wojciesko, Ewa$$b9
000291272 7001_ $$aBasso, Daniela$$b10
000291272 7001_ $$aArcidiacono, Paolo Giorgio$$b11
000291272 7001_ $$aPetrone, Maria Chiara$$b12
000291272 7001_ $$aCarrara, Silvia$$b13
000291272 7001_ $$aGötz, Mara$$b14
000291272 7001_ $$aBunduc, Stefania$$b15
000291272 7001_ $$aHolleczek, Bernd$$b16
000291272 7001_ $$aAoki, Mateus Nóbrega$$b17
000291272 7001_ $$aUzunoglu, Faik G$$b18
000291272 7001_ $$aZanette, Dalila Lucíola$$b19
000291272 7001_ $$aMambrini, Andrea$$b20
000291272 7001_ $$aJamroziak, Krzysztof$$b21
000291272 7001_ $$aOliverius, Martin$$b22
000291272 7001_ $$aLovecek, Martin$$b23
000291272 7001_ $$aCavestro, Giulia Martina$$b24
000291272 7001_ $$aMilanetto, Anna Caterina$$b25
000291272 7001_ $$aPeduzzi, Giulia$$b26
000291272 7001_ $$aDuchonova, Beatrice Mohelnikova$$b27
000291272 7001_ $$aIzbicki, Jakob R$$b28
000291272 7001_ $$aZalinkevicius, Rimantas$$b29
000291272 7001_ $$aHlavac, Viktor$$b30
000291272 7001_ $$avan Eijck, Casper H J$$b31
000291272 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b32$$udkfz
000291272 7001_ $$aVanella, Giuseppe$$b33
000291272 7001_ $$aVokacova, Klara$$b34
000291272 7001_ $$aSoucek, Pavel$$b35
000291272 7001_ $$00000-0002-8831-7349$$aTavano, Francesca$$b36
000291272 7001_ $$aPerri, Francesco$$b37
000291272 7001_ $$aCapurso, Gabriele$$b38
000291272 7001_ $$aHussein, Tamás$$b39
000291272 7001_ $$aKiudelis, Mindaugas$$b40
000291272 7001_ $$aKupcinskas, Juozas$$b41
000291272 7001_ $$aBusch, Olivier R$$b42
000291272 7001_ $$aMorelli, Luca$$b43
000291272 7001_ $$aTheodoropoulos, George E$$b44
000291272 7001_ $$aTestoni, Sabrina Gloria Giulia$$b45
000291272 7001_ $$aAdamonis, Kestutis$$b46
000291272 7001_ $$aNeoptolemos, John P$$b47
000291272 7001_ $$00000-0002-3295-6811$$aGazouli, Maria$$b48
000291272 7001_ $$aPasquali, Claudio$$b49
000291272 7001_ $$aKormos, Zita$$b50
000291272 7001_ $$aSkalicky, Pavel$$b51
000291272 7001_ $$aPezzilli, Raffaele$$b52
000291272 7001_ $$aSperti, Cosimo$$b53
000291272 7001_ $$aKauffmann, Emanuele$$b54
000291272 7001_ $$aBüchler, Markus W$$b55
000291272 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b56$$udkfz
000291272 7001_ $$aHegyi, Péter$$b57
000291272 7001_ $$aCapretti, Giovanni$$b58
000291272 7001_ $$aLawlor, Rita T$$b59
000291272 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b60$$eLast author$$udkfz
000291272 7001_ $$00000-0003-3220-9944$$aCampa, Daniele$$b61
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