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@ARTICLE{Corradi:291272,
      author       = {C. Corradi and G. Lencioni and A. Felici and C. Rizzato and
                      M. Gentiluomo and S. Ermini and L. Archibugi and A.
                      Mickevicius and M. Lucchesi and E. Malecka-Wojciesko and D.
                      Basso and P. G. Arcidiacono and M. C. Petrone and S. Carrara
                      and M. Götz and S. Bunduc and B. Holleczek and M. N. Aoki
                      and F. G. Uzunoglu and D. L. Zanette and A. Mambrini and K.
                      Jamroziak and M. Oliverius and M. Lovecek and G. M. Cavestro
                      and A. C. Milanetto and G. Peduzzi and B. M. Duchonova and
                      J. R. Izbicki and R. Zalinkevicius and V. Hlavac and C. H.
                      J. van Eijck and H. Brenner$^*$ and G. Vanella and K.
                      Vokacova and P. Soucek and F. Tavano and F. Perri and G.
                      Capurso and T. Hussein and M. Kiudelis and J. Kupcinskas and
                      O. R. Busch and L. Morelli and G. E. Theodoropoulos and S.
                      G. G. Testoni and K. Adamonis and J. P. Neoptolemos and M.
                      Gazouli and C. Pasquali and Z. Kormos and P. Skalicky and R.
                      Pezzilli and C. Sperti and E. Kauffmann and M. W. Büchler
                      and B. Schöttker$^*$ and P. Hegyi and G. Capretti and R. T.
                      Lawlor and F. Canzian$^*$ and D. Campa},
      title        = {{P}otential association between {PSCA} rs2976395 functional
                      variant and pancreatic cancer risk.},
      journal      = {International journal of cancer},
      volume       = {155},
      number       = {8},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01355},
      pages        = {1432-1442},
      year         = {2024},
      note         = {#LA:C055# / 2024 Oct 15;155(8):1432-1442},
      abstract     = {Correlated regions of systemic interindividual variation
                      (CoRSIV) represent a small proportion of the human genome
                      showing DNA methylation patterns that are the same in all
                      human tissues, are different among individuals, and are
                      partially regulated by genetic variants in cis. In this
                      study we aimed at investigating single-nucleotide
                      polymorphisms (SNPs) within CoRSIVs and their involvement
                      with pancreatic ductal adenocarcinoma (PDAC) risk. We
                      analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in
                      14,394 cases and 247,022 controls of European and Asian
                      descent. We observed that the A allele of the rs2976395 SNP
                      was associated with increased PDAC risk in Europeans (p =
                      2.81 × 10-5). This SNP lies in the prostate stem cell
                      antigen gene and is in perfect linkage disequilibrium with a
                      variant (rs2294008) that has been reported to be associated
                      with risk of many other cancer types. The A allele is
                      associated with the DNA methylation level of the gene
                      according to the PanCan-meQTL database and with
                      overexpression according to QTLbase. The expression of the
                      gene has been observed to be deregulated in many tumors of
                      the gastrointestinal tract including pancreatic cancer;
                      however, functional studies are needed to elucidate the
                      function relevance of the association.},
      keywords     = {DNA methylation (Other) / pancreatic cancer (Other) / risk
                      factors (Other) / single‐nucleotide polymorphism (Other)},
      cin          = {C070 / C120 / HD01 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38924078},
      doi          = {10.1002/ijc.35046},
      url          = {https://inrepo02.dkfz.de/record/291272},
}