TY  - JOUR
AU  - Guidara, Souhir
AU  - Seyve, Antoine
AU  - Poncet, Delphine
AU  - Leonce, Camille
AU  - Bringuier, Pierre-Paul
AU  - McLeer, Anne
AU  - Sturm, Dominik
AU  - Cartalat, Stéphanie
AU  - Picart, Thiebaud
AU  - Ferrari, Anthony
AU  - Hench, Jürgen
AU  - Frank, Stephan
AU  - Meyronet, David
AU  - Ducray, François
AU  - Barritault, Marc
TI  - Characteristics of H3K27M-mutant diffuse gliomas with a non-midline location.
JO  - Journal of neuro-oncology
VL  - 169
IS  - 2
SN  - 0167-594X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - DKFZ-2024-01377
SP  - 391-398
PY  - 2024
N1  - 2024 Sep;169(2):391-398
AB  - Diffuse midline gliomas (DMG) with H3K27 alterations (H3K27M-DMG) are a highly aggressive form of brain cancer. In rare cases, H3K27 mutations have been observed in diffuse non-midline gliomas (DNMG). It is currently unclear how these tumors should be classified. Herein, we analyze the characteristics of DNMG with H3K27M mutations.We reviewed the clinical, radiological and histological characteristics of all patients with an H3K27M mutated diffuse glioma diagnosed in our institution, between 2016 and 2023, to identify cases with a non-midline location. We then performed a molecular characterization (DNA methylation profiling, whole genome and transcriptome sequencing or targeted sequencing) of patients with an H3K27M-mutant DNMG and reviewed previously reported cases.Among 51 patients (18 children and 33 adults) diagnosed with an H3K27M diffuse glioma, we identified two patients (4
KW  - Diffuse intrinsic pontine glioma (Other)
KW  - Diffuse midline glioma H3 K27-altered (Other)
KW  - H3K27M (Other)
KW  - H3K28M (Other)
KW  - Methylation (Other)
KW  - Non-midline (Other)
KW  - Pediatric glioma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38937309
DO  - DOI:10.1007/s11060-024-04733-z
UR  - https://inrepo02.dkfz.de/record/291389
ER  -