TY  - JOUR
AU  - Zhang, Ke
AU  - Triphan, Simon M F
AU  - Wielpütz, Mark O
AU  - Ziener, Christian H
AU  - Ladd, Mark E
AU  - Schlemmer, Heinz-Peter
AU  - Kauczor, Hans-Ulrich
AU  - Sedlaczek, Oliver
AU  - Kurz, Felix Tobias
TI  - Non-contrast free-breathing liver perfusion imaging using velocity selective ASL combined with prospective motion compensation.
JO  - Zeitschrift für medizinische Physik
VL  - 35
IS  - 1
SN  - 0939-3889
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-01413
SP  - 87-97
PY  - 2025
N1  - #EA:E010#LA:E010# / Volume 35, Issue 1, February 2025, Pages 87-97
AB  - To apply velocity selective arterial spin labeling (VSASL) combined with a navigator-based (NAV) prospective motion compensation method for a free-breathing liver perfusion measurement without contrast agent.Sinc-modulated Velocity Selective Inversion (sinc-VSI) pulses were applied as labeling and control pulses. In order to account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI based readouts, navigator and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. The sinc-VSI without velocity-selective gradients during the control condition but with velocity-selective gradients along all three directions during labeling was chosen for the VSASL. The VSASL was compared with pseudo-continuous ASL (pCASL) methods, which selectively tagged the moving spins using a tagging plane placed at the portal vein and hepatic artery.The motion caused by respiratory activity was effectively computed using the navigator signal. The coefficients of variation (CoV) of average liver voxel in NAV were significantly decreased when compared to breath-hold (BH), with an average reduction of 29.4 ± 18.44
KW  - Liver perfusion (Other)
KW  - Navigator-based slice tracking (Other)
KW  - Prospective motion compensation (Other)
KW  - Velocity selective arterial spin labeling (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38960810
DO  - DOI:10.1016/j.zemedi.2024.06.001
UR  - https://inrepo02.dkfz.de/record/291450
ER  -