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000291457 041__ $$aEnglish
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000291457 1001_ $$aKamp, Benedikt$$b0
000291457 245__ $$aSodium MRI of the Lumbar Intervertebral Discs of the Human Spine: An Ex Vivo Study.
000291457 260__ $$aNew York, NY$$bWiley-Liss$$c2025
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000291457 500__ $$a2025 Mar;61(3):1503-1512
000291457 520__ $$aLower back pain affects 75%-85% of people at some point in their lives. The detection of biochemical changes with sodium (23Na) MRI has potential to enable an earlier and more accurate diagnosis.To measure 23Na relaxation times and apparent tissue sodium concentration (aTSC) in ex-vivo intervertebral discs (IVDs), and to investigate the relationship between aTSC and histological Thompson grade.Ex-vivo.Thirty IVDs from the lumbar spines of 11 human body donors (4 female, 7 male, mean age 86 ± 8 years).3 T; density-adapted 3D radial sequence (DA-3D-RAD).IVD 23Na longitudinal (T1), short and long transverse (T2s* and T2l*) relaxation times and the proportion of the short transverse relaxation (ps) were calculated for one IVD per spine sample (11 IVDs). Furthermore, aTSCs were calculated for all IVDs. The degradation of the IVDs was assessed via histological Thompson grading.A Kendall Tau correlation (τ) test was performed between the aTSCs and the Thompson grades. The significance level was set to P < 0.05.Mean 23Na relaxation parameters of a subset of 11 IVDs were T1 = 9.8 ± 1.3 msec, T2s* = 0.7 ± 0.1 msec, T2l* = 7.3 ± 1.1 msec, and ps = 32.7 ± 4.0%. A total of 30 IVDs were examined, of which 3 had Thompson grade 1, 4 had grade 2, 5 had grade 3, 5 had grade 4, and 13 had grade 5. The aTSC decreased with increasing degradation, being 274.6 ± 18.9 mM for Thompson grade 1 and 190.5 ± 29.5 mM for Thompson grade 5. The correlation between whole IVD aTSC and Thompson grade was significant and strongly negative (τ = -0.56).This study showed a significant correlation between aTSC and degenerative IVD changes. Consequently, aTSC has potential to be useful as an indicator of degenerative spinal changes.2 TECHNICAL EFFICACY: Stage 1.
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000291457 650_7 $$2Other$$a23Na MRI
000291457 650_7 $$2Other$$a23Na relaxation times
000291457 650_7 $$2Other$$aIVD
000291457 650_7 $$2Other$$aex vivo
000291457 650_7 $$2Other$$aintervertebral disc
000291457 650_7 $$2Other$$asodium MRI
000291457 7001_ $$00000-0003-1095-1283$$aRadke, Karl Ludger$$b1
000291457 7001_ $$aKnet, Marek$$b2
000291457 7001_ $$aStrunk, Rosanna$$b3
000291457 7001_ $$aGallinnis, Patrik J$$b4
000291457 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b5$$udkfz
000291457 7001_ $$aFiller, Timm J$$b6
000291457 7001_ $$aAntoch, Gerald$$b7
000291457 7001_ $$aAbrar, Daniel B$$b8
000291457 7001_ $$aFrenken, Miriam$$b9
000291457 7001_ $$aWittsack, Hans-Jörg$$b10
000291457 7001_ $$aMüller-Lutz, Anja$$b11
000291457 773__ $$0PERI:(DE-600)1497154-9$$a10.1002/jmri.29521$$gp. jmri.29521$$n3$$p1503-1512$$tJournal of magnetic resonance imaging$$v61$$x1053-1807$$y2025
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