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000291550 245__ $$aLong-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution.
000291550 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000291550 520__ $$aIt is well established that the medial prefrontal cortex (mPFC) exerts top-down control of many behaviors, but little is known regarding how cross-talk between distinct areas of the mPFC influences top-down signaling. We performed virus-mediated tracing and functional studies in male mice, homing in on GABAergic projections whose axons are located mainly in layer 1 and that connect two areas of the mPFC, namely the prelimbic area (PrL) with the cingulate area 1 and 2 (Cg1/2). We revealed the identity of the targeted neurons that comprise two distinct types of layer 1 GABAergic interneurons, namely single-bouquet cells (SBCs) and neurogliaform cells (NGFs), and propose that this connectivity links GABAergic projection neurons with cortical canonical circuits. In vitro electrophysiological and in vivo calcium imaging studies support the notion that the GABAergic projection neurons from the PrL to the Cg1/2 exert a crucial role in regulating the activity in the target area by disinhibiting layer 5 output neurons. Finally, we demonstrated that recruitment of these projections affects impulsivity and mechanical responsiveness, behaviors which are known to be modulated by Cg1/2 activity.
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000291550 650_2 $$2MeSH$$aAnimals
000291550 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000291550 650_2 $$2MeSH$$aPrefrontal Cortex: cytology
000291550 650_2 $$2MeSH$$aMale
000291550 650_2 $$2MeSH$$aGyrus Cinguli: physiology
000291550 650_2 $$2MeSH$$aGyrus Cinguli: cytology
000291550 650_2 $$2MeSH$$aGABAergic Neurons: metabolism
000291550 650_2 $$2MeSH$$aGABAergic Neurons: physiology
000291550 650_2 $$2MeSH$$aMice
000291550 650_2 $$2MeSH$$aInterneurons: physiology
000291550 650_2 $$2MeSH$$aMice, Inbred C57BL
000291550 650_2 $$2MeSH$$aNerve Net: physiology
000291550 650_2 $$2MeSH$$aNeural Pathways: physiology
000291550 7001_ $$0P:(DE-He78)4a396933fbdc9d884dd78995f1f65de3$$aMacLaren, Duncan$$b1$$eFirst author$$udkfz
000291550 7001_ $$0P:(DE-He78)3c559fac86c30c4ea43ff8df786173bd$$aLiu, Yu-Chao$$b2$$eFirst author$$udkfz
000291550 7001_ $$0P:(DE-He78)5b864248a2d378013c80cd8fcacb0629$$aYaqubi, Kaneschka$$b3
000291550 7001_ $$0P:(DE-He78)a2c83db8ca7c6a0fe0bae2f43d2b3a29$$aWojak, Birgit$$b4
000291550 7001_ $$00000-0002-9332-5749$$aMonyer, Hannah$$b5$$eLast author
000291550 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-50055-z$$gVol. 15, no. 1, p. 5772$$n1$$p5772$$tNature Communications$$v15$$x2041-1723$$y2024
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