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@ARTICLE{Utashiro:291550,
      author       = {N. Utashiro$^*$ and D. MacLaren$^*$ and Y.-C. Liu$^*$ and
                      K. Yaqubi$^*$ and B. Wojak$^*$ and H. Monyer$^*$},
      title        = {{L}ong-range inhibition from prelimbic to cingulate areas
                      of the medial prefrontal cortex enhances network activity
                      and response execution.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-01441},
      pages        = {5772},
      year         = {2024},
      note         = {#EA:A230#LA:A230#},
      abstract     = {It is well established that the medial prefrontal cortex
                      (mPFC) exerts top-down control of many behaviors, but little
                      is known regarding how cross-talk between distinct areas of
                      the mPFC influences top-down signaling. We performed
                      virus-mediated tracing and functional studies in male mice,
                      homing in on GABAergic projections whose axons are located
                      mainly in layer 1 and that connect two areas of the mPFC,
                      namely the prelimbic area (PrL) with the cingulate area 1
                      and 2 (Cg1/2). We revealed the identity of the targeted
                      neurons that comprise two distinct types of layer 1
                      GABAergic interneurons, namely single-bouquet cells (SBCs)
                      and neurogliaform cells (NGFs), and propose that this
                      connectivity links GABAergic projection neurons with
                      cortical canonical circuits. In vitro electrophysiological
                      and in vivo calcium imaging studies support the notion that
                      the GABAergic projection neurons from the PrL to the Cg1/2
                      exert a crucial role in regulating the activity in the
                      target area by disinhibiting layer 5 output neurons.
                      Finally, we demonstrated that recruitment of these
                      projections affects impulsivity and mechanical
                      responsiveness, behaviors which are known to be modulated by
                      Cg1/2 activity.},
      keywords     = {Animals / Prefrontal Cortex: physiology / Prefrontal
                      Cortex: cytology / Male / Gyrus Cinguli: physiology / Gyrus
                      Cinguli: cytology / GABAergic Neurons: metabolism /
                      GABAergic Neurons: physiology / Mice / Interneurons:
                      physiology / Mice, Inbred C57BL / Nerve Net: physiology /
                      Neural Pathways: physiology},
      cin          = {A230},
      ddc          = {500},
      cid          = {I:(DE-He78)A230-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38982042},
      doi          = {10.1038/s41467-024-50055-z},
      url          = {https://inrepo02.dkfz.de/record/291550},
}