Home > Publications database > Long-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution. > print

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100 1 _ |a Utashiro, Nao
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245 _ _ |a Long-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution.
260 _ _ |a [London]
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|b Nature Publishing Group UK
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520 _ _ |a It is well established that the medial prefrontal cortex (mPFC) exerts top-down control of many behaviors, but little is known regarding how cross-talk between distinct areas of the mPFC influences top-down signaling. We performed virus-mediated tracing and functional studies in male mice, homing in on GABAergic projections whose axons are located mainly in layer 1 and that connect two areas of the mPFC, namely the prelimbic area (PrL) with the cingulate area 1 and 2 (Cg1/2). We revealed the identity of the targeted neurons that comprise two distinct types of layer 1 GABAergic interneurons, namely single-bouquet cells (SBCs) and neurogliaform cells (NGFs), and propose that this connectivity links GABAergic projection neurons with cortical canonical circuits. In vitro electrophysiological and in vivo calcium imaging studies support the notion that the GABAergic projection neurons from the PrL to the Cg1/2 exert a crucial role in regulating the activity in the target area by disinhibiting layer 5 output neurons. Finally, we demonstrated that recruitment of these projections affects impulsivity and mechanical responsiveness, behaviors which are known to be modulated by Cg1/2 activity.
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650 _ 2 |a Animals
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650 _ 2 |a Prefrontal Cortex: physiology
|2 MeSH
650 _ 2 |a Prefrontal Cortex: cytology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Gyrus Cinguli: physiology
|2 MeSH
650 _ 2 |a Gyrus Cinguli: cytology
|2 MeSH
650 _ 2 |a GABAergic Neurons: metabolism
|2 MeSH
650 _ 2 |a GABAergic Neurons: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Interneurons: physiology
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
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650 _ 2 |a Nerve Net: physiology
|2 MeSH
650 _ 2 |a Neural Pathways: physiology
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700 1 _ |a MacLaren, Duncan
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700 1 _ |a Liu, Yu-Chao
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700 1 _ |a Yaqubi, Kaneschka
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700 1 _ |a Wojak, Birgit
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700 1 _ |a Monyer, Hannah
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773 _ _ |a 10.1038/s41467-024-50055-z
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