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000291687 1001_ $$0P:(DE-He78)cf4656ab05919cc784af4e9812f5a9fa$$aGrözinger, Martin$$b0$$eFirst author$$udkfz
000291687 245__ $$aDetection of myeloma-associated osteolytic bone lesions with energy-integrating and photon-counting detector CT .[Erkennung myelomassoziierter osteolytischer Knochenläsionen mit energieintegrierender und photonenzählender Detektor-Computertomographie].
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000291687 500__ $$a#EA:E010#LA:E010# / 2024 Nov;64(Suppl 1):24-31
000291687 520__ $$aA recent innovation in computed tomography (CT) imaging has been the introduction of photon-counting detector CT (PCD-CT) systems, which are able to register the number and the energy level of incoming x‑ray photons and have smaller detector elements compared with conventional CT scanners that operate with energy-integrating detectors (EID-CT).The study aimed to evaluate the potential benefits of a novel, non-CE certified PCD-CT in detecting myeloma-associated osteolytic bone lesions (OL) compared with a state-of-the-art EID-CT.Nine patients with multiple myeloma stage III (according to Durie and Salmon) underwent magnetic resonance imaging (MRI), EID-CT, and PCD-CT of the lower lumbar spine and pelvis. The PCD-CT and EID-CT images of all myeloma lesions that were visible in clinical MRI scans were reviewed by three radiologists for corresponding OL. Additionally, the visualization of destructions to cancellous or cortical bone, and trabecular structures, was compared between PCD-CT and EID-CT.Readers detected 21% more OL in PCD-CT than in EID-CT images (138 vs. 109; p < 0.0001). The sensitivity advantage of PCD-CT in lesion detection increased with decreasing lesion size. The visualization quality of cancellous and cortical destructions as well as of trabecular structures was rated higher by all three readers in PCD-CT images (mean image quality improvements for PCD-CT over EID-CT were +0.45 for cancellous and +0.13 for cortical destructions).For myeloma-associated OL, PCD-CT demonstrated significantly higher sensitivity, especially with small size. Visualization of bone tissue and lesions was considered significantly better in PCD-CT than in EID-CT. This implies that PCD-CT scanners could potentially be used in the early detection of myeloma-associated bone lesions.
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000291687 650_7 $$2Other$$aImage quality
000291687 650_7 $$2Other$$aLesion detection
000291687 650_7 $$2Other$$aMultiple myeloma
000291687 650_7 $$2Other$$aOsteolytic lesions
000291687 650_7 $$2Other$$aPhoton-counting CT
000291687 7001_ $$0P:(DE-He78)e7c860fe438c12cbe5f071b3f86d5738$$aWennmann, Markus$$b1$$udkfz
000291687 7001_ $$0P:(DE-He78)14909c75431f33f953a7ab4ad3bd7d51$$aSawall, Stefan$$b2$$udkfz
000291687 7001_ $$0P:(DE-He78)b4371bfbf1c75613142130d9b68434aa$$aWehrse, Eckhard$$b3
000291687 7001_ $$aSedaghat, Sam$$b4
000291687 7001_ $$0P:(DE-He78)2af28acfaad8f466abb166306f9597bd$$aNeelsen, Christian$$b5$$udkfz
000291687 7001_ $$0P:(DE-He78)adc25b1dbf85abdffe5d2300d1265031$$aBauer, Fabian$$b6$$udkfz
000291687 7001_ $$aGoldschmidt, Hartmut$$b7
000291687 7001_ $$0P:(DE-He78)7dc85735e114a4ace658ba1450a2cca6$$aWeru, Vivienn$$b8$$udkfz
000291687 7001_ $$0P:(DE-He78)a56941777fbaf0ca1008366e7e16667f$$aZiener, Christian H$$b9$$udkfz
000291687 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b10$$udkfz
000291687 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b11$$udkfz
000291687 7001_ $$0P:(DE-He78)d7135c1486ffd923f71735d40a3d7a0c$$aRotkopf, Lukas Thomas$$b12$$eLast author$$udkfz
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