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@ARTICLE{Grzinger:291687,
      author       = {M. Grözinger$^*$ and M. Wennmann$^*$ and S. Sawall$^*$ and
                      E. Wehrse$^*$ and S. Sedaghat and C. Neelsen$^*$ and F.
                      Bauer$^*$ and H. Goldschmidt and V. Weru$^*$ and C. H.
                      Ziener$^*$ and A. Kopp-Schneider$^*$ and H.-P. Schlemmer$^*$
                      and L. T. Rotkopf$^*$},
      title        = {{D}etection of myeloma-associated osteolytic bone lesions
                      with energy-integrating and photon-counting detector {CT}
                      .[{E}rkennung myelomassoziierter osteolytischer
                      {K}nochenläsionen mit energieintegrierender und
                      photonenzählender {D}etektor-{C}omputertomographie].},
      journal      = {Die Radiologie},
      volume       = {64},
      number       = {Suppl 1},
      issn         = {2731-7048},
      address      = {[Berlin]},
      publisher    = {Springer Medizin Verlag GmbH},
      reportid     = {DKFZ-2024-01491},
      pages        = {24-31},
      year         = {2024},
      note         = {#EA:E010#LA:E010# / 2024 Nov;64(Suppl 1):24-31},
      abstract     = {A recent innovation in computed tomography (CT) imaging has
                      been the introduction of photon-counting detector CT
                      (PCD-CT) systems, which are able to register the number and
                      the energy level of incoming x‑ray photons and have
                      smaller detector elements compared with conventional CT
                      scanners that operate with energy-integrating detectors
                      (EID-CT).The study aimed to evaluate the potential benefits
                      of a novel, non-CE certified PCD-CT in detecting
                      myeloma-associated osteolytic bone lesions (OL) compared
                      with a state-of-the-art EID-CT.Nine patients with multiple
                      myeloma stage III (according to Durie and Salmon) underwent
                      magnetic resonance imaging (MRI), EID-CT, and PCD-CT of the
                      lower lumbar spine and pelvis. The PCD-CT and EID-CT images
                      of all myeloma lesions that were visible in clinical MRI
                      scans were reviewed by three radiologists for corresponding
                      OL. Additionally, the visualization of destructions to
                      cancellous or cortical bone, and trabecular structures, was
                      compared between PCD-CT and EID-CT.Readers detected $21\%$
                      more OL in PCD-CT than in EID-CT images (138 vs. 109; p <
                      0.0001). The sensitivity advantage of PCD-CT in lesion
                      detection increased with decreasing lesion size. The
                      visualization quality of cancellous and cortical
                      destructions as well as of trabecular structures was rated
                      higher by all three readers in PCD-CT images (mean image
                      quality improvements for PCD-CT over EID-CT were +0.45 for
                      cancellous and +0.13 for cortical destructions).For
                      myeloma-associated OL, PCD-CT demonstrated significantly
                      higher sensitivity, especially with small size.
                      Visualization of bone tissue and lesions was considered
                      significantly better in PCD-CT than in EID-CT. This implies
                      that PCD-CT scanners could potentially be used in the early
                      detection of myeloma-associated bone lesions.},
      keywords     = {Image quality (Other) / Lesion detection (Other) / Multiple
                      myeloma (Other) / Osteolytic lesions (Other) /
                      Photon-counting CT (Other)},
      cin          = {E010 / E025 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E025-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39020050},
      doi          = {10.1007/s00117-024-01344-7},
      url          = {https://inrepo02.dkfz.de/record/291687},
}