%0 Journal Article
%A Aglago, Elom K
%A Qu, Conghui
%A Harlid, Sophia
%A Phipps, Amanda I
%A Steinfelder, Robert S
%A Ogino, Shuji
%A Thomas, Claire E
%A Hsu, Li
%A Toland, Amanda E
%A Brenner, Hermann
%A Berndt, Sonja I
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Cao, Yin
%A Chan, Andrew T
%A Drew, David A
%A Figueiredo, Jane C
%A French, Amy J
%A Gallinger, Steven
%A Georgeson, Peter
%A Giannakis, Marios
%A Goode, Ellen L
%A Gruber, Stephen B
%A Gunter, Marc J
%A Harrison, Tabitha A
%A Hoffmeister, Michael
%A Huang, Wen-Yi
%A Hullar, Meredith Aj
%A Huyghe, Jeroen R
%A Jenkins, Mark A
%A Lynch, Brigid M
%A Moreno, Victor
%A Murphy, Neil
%A Newton, Christina C
%A Nowak, Jonathan A
%A Obón-Santacana, Mireia
%A Sun, Wei
%A Ugai, Tomotaka
%A Um, Caroline Y
%A Zaidi, Syed H
%A Tsilidis, Konstantinos K
%A van Guelpen, Bethany
%A Peters, Ulrike
%T Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing.
%J The American journal of clinical nutrition
%V 120
%N 3
%@ 0095-9871
%C Amsterdam
%I Elsevier
%M DKFZ-2024-01499
%P 664-673
%D 2024
%Z 2024 Sep;120(3):664-673
%X Folate is involved in multiple genetic, epigenetic, and metabolic processes, and inadequate folate intake has been associated with an increased risk of cancer.We examined whether folate intake is differentially associated with colorectal cancer (CRC) risk according to somatic mutations in genes linked to CRC using targeted sequencing.Participants within two large CRC consortia with available information on dietary folate, supplemental folic acid, and total folate intake were included. Colorectal tumor samples from cases were sequenced for the presence of non-silent mutations in 105 genes and 6 signaling pathways (IGF2/PI3K, MMR, RTK/RAS, TGF-β, WNT, TP53/ATM). Multinomial logistic regression models were run comparing mutated/non-mutated CRC cases to controls to compute multivariable-adjusted odds ratios (ORs) with 95
%K colorectal cancer (Other)
%K folate (Other)
%K folic acid (Other)
%K molecular subtypes (Other)
%K somatic mutations (Other)
%K tumor (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39025327
%R 10.1016/j.ajcnut.2024.07.012
%U https://inrepo02.dkfz.de/record/291763