TY  - JOUR
AU  - Stocker, Hannah
AU  - Gentiluomo, Manuel
AU  - Trares, Kira
AU  - Beyer, Léon
AU  - Stevenson-Hoare, Joshua
AU  - Rujescu, Dan
AU  - Holleczek, Bernd
AU  - Beyreuther, Konrad
AU  - Gerwert, Klaus
AU  - Schöttker, Ben
AU  - Campa, Daniele
AU  - Canzian, Federico
AU  - Brenner, Hermann
TI  - Mitochondrial DNA abundance in blood is associated with Alzheimer's disease- and dementia-risk.
JO  - Molecular psychiatry
VL  - 30
SN  - 1359-4184
CY  - London
PB  - Macmillan
M1  - DKFZ-2024-01505
SP  - 131–139
PY  - 2025
N1  - #EA:C070#LA:C070# /  30, pages 131–139 (2025)
AB  - The mitochondrial cascade hypothesis of Alzheimer's disease (AD) has been portrayed through molecular, cellular, and animal studies; however large epidemiological studies are lacking. This study aimed to explore the association of mitochondrial DNA copy number (mtDNAcn), a marker representative of mtDNA abundance per cell, with risk of incident all-cause dementia, AD, and vascular dementia diagnosis within 17 years and dementia-related blood biomarkers (P-tau181, GFAP, and NfL). Additionally, sex-stratified analyses were completed. In this German population-based cohort study (ESTHER), 9940 participants aged 50-75 years were enrolled by general practitioners and followed for 17 years. Participants were included in this study if information on dementia status and blood-based mtDNAcn measured via real-time polymerase chain reaction were available. In a nested case-control approach, a subsample of participants additionally had measurements of P-tau181, GFAP, and NfL in blood samples taken at baseline. Of 4913 participants eligible for analyses, 386 were diagnosed with incident all-cause dementia, including 130 AD and 143 vascular dementia cases, while 4527 participants remained without dementia diagnosis within 17 years. Participants with low mtDNAcn (lowest 10
LB  - PUB:(DE-HGF)16
C6  - pmid:39009700
DO  - DOI:10.1038/s41380-024-02670-x
UR  - https://inrepo02.dkfz.de/record/291769
ER  -