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000291771 041__ $$aEnglish
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000291771 1001_ $$00000-0003-4911-6891$$aStockis, Julie$$b0
000291771 245__ $$aCross-talk between ILC2 and Gata3high Tregs locally constrains adaptive type 2 immunity.
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000291771 520__ $$aRegulatory T cells (Tregs) control adaptive immunity and restrain type 2 inflammation in allergic disease. Interleukin-33 promotes the expansion of tissue-resident Tregs and group 2 innate lymphoid cells (ILC2s); however, how Tregs locally coordinate their function within the inflammatory niche is not understood. Here, we show that ILC2s are critical orchestrators of Treg function. Using spatial, cellular, and molecular profiling of the type 2 inflamed niche, we found that ILC2s and Tregs engage in a direct (OX40L-OX40) and chemotaxis-dependent (CCL1-CCR8) cellular dialogue that enforces the local accumulation of Gata3high Tregs, which are transcriptionally and functionally adapted to the type 2 environment. Genetic interruption of ILC2-Treg communication resulted in uncontrolled type 2 lung inflammation after allergen exposure. Mechanistically, we found that Gata3high Tregs can modulate the local bioavailability of the costimulatory molecule OX40L, which subsequently controlled effector memory T helper 2 cell numbers. Hence, ILC2-Treg interactions represent a critical feedback mechanism to control adaptive type 2 immunity.
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000291771 650_7 $$2NLM Chemicals$$aGATA3 Transcription Factor
000291771 650_7 $$2NLM Chemicals$$aGata3 protein, mouse
000291771 650_2 $$2MeSH$$aAnimals
000291771 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory: immunology
000291771 650_2 $$2MeSH$$aGATA3 Transcription Factor: immunology
000291771 650_2 $$2MeSH$$aGATA3 Transcription Factor: metabolism
000291771 650_2 $$2MeSH$$aMice
000291771 650_2 $$2MeSH$$aAdaptive Immunity: immunology
000291771 650_2 $$2MeSH$$aMice, Inbred C57BL
000291771 650_2 $$2MeSH$$aLymphocytes: immunology
000291771 650_2 $$2MeSH$$aImmunity, Innate: immunology
000291771 650_2 $$2MeSH$$aMice, Knockout
000291771 650_2 $$2MeSH$$aTh2 Cells: immunology
000291771 650_2 $$2MeSH$$aFemale
000291771 7001_ $$00009-0007-6287-3543$$aYip, Thomas$$b1
000291771 7001_ $$00000-0002-1740-9350$$aMoreno-Vicente, Julia$$b2
000291771 7001_ $$00000-0003-3884-7373$$aBurton, Oliver$$b3
000291771 7001_ $$aSamarakoon, Youhani$$b4
000291771 7001_ $$00000-0001-6433-6417$$aSchuijs, Martijn J$$b5
000291771 7001_ $$aRaghunathan, Shwetha$$b6
000291771 7001_ $$aGarcia, Celine$$b7
000291771 7001_ $$00009-0008-1337-6484$$aLuo, Weike$$b8
000291771 7001_ $$00000-0003-4354-4713$$aWhiteside, Sarah K$$b9
000291771 7001_ $$00000-0002-2364-4621$$aPng, Shaun$$b10
000291771 7001_ $$aSimpson, Charlotte$$b11
000291771 7001_ $$00009-0002-5634-7233$$aMonk, Stela$$b12
000291771 7001_ $$00000-0002-2985-5059$$aSawle, Ashley$$b13
000291771 7001_ $$00000-0003-2993-6374$$aYin, Kelvin$$b14
000291771 7001_ $$00009-0008-3309-7589$$aBarbieri, Johanna$$b15
000291771 7001_ $$00000-0002-3667-6817$$aPapadopoulos, Panagiotis$$b16
000291771 7001_ $$00000-0002-9530-7106$$aWong, Hannah$$b17
000291771 7001_ $$0P:(DE-He78)86fa3316b7be0d661065d02b3baec3d6$$aRodewald, Hans-Reimer$$b18$$udkfz
000291771 7001_ $$00000-0003-1123-1464$$aVyse, Timothy$$b19
000291771 7001_ $$00000-0001-9757-2512$$aMcKenzie, Andrew N J$$b20
000291771 7001_ $$00000-0003-2077-089X$$aCragg, Mark S$$b21
000291771 7001_ $$00000-0001-5990-9604$$aHoare, Matthew$$b22
000291771 7001_ $$00000-0003-3757-7594$$aWithers, David R$$b23
000291771 7001_ $$00000-0002-4580-1990$$aFehling, Hans Jörg$$b24
000291771 7001_ $$00000-0002-5392-1853$$aRoychoudhuri, Rahul$$b25
000291771 7001_ $$00000-0002-6272-4085$$aListon, Adrian$$b26
000291771 7001_ $$00000-0001-9773-0023$$aHalim, Timotheus Y F$$b27
000291771 773__ $$0PERI:(DE-600)2862556-0$$a10.1126/sciimmunol.adl1903$$gVol. 9, no. 97, p. eadl1903$$n97$$peadl1903$$tScience immunology$$v9$$x2470-9468$$y2024
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