TY  - JOUR
AU  - Viallon, Vivian
AU  - Freisling, Heinz
AU  - Matta, Komodo
AU  - Nannsen, Anne Østergaard
AU  - Dahm, Christina C
AU  - Tjønneland, Anne
AU  - Eriksen, Anne Kirstine
AU  - Kaaks, Rudolf
AU  - Katzke, Verena A
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Tagliabue, Giovanna
AU  - Simeon, Vittorio
AU  - Tumino, Rosario
AU  - Milani, Lorenzo
AU  - Derksen, Jeroen W G
AU  - van der Schouw, Yvonne T
AU  - Nøst, Therese Haugdahl
AU  - Borch, Kristin Benjaminsen
AU  - Sandanger, Torkjel M
AU  - Quirós, J Ramón
AU  - Rodriguez-Barranco, Miguel
AU  - Bonet, Catalina
AU  - Aizpurua-Atxega, Amaia
AU  - Cirera, Lluís
AU  - Guevara, Marcela
AU  - Sundström, Björn
AU  - Winkvist, Anna
AU  - Heath, Alicia K
AU  - Gunter, Marc J
AU  - Weiderpass, Elisabete
AU  - Johansson, Mattias
AU  - Ferrari, Pietro
TI  - On the use of the healthy lifestyle index to investigate specific disease outcomes.
JO  - Scientific reports
VL  - 14
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2024-01517
SP  - 16330
PY  - 2024
AB  - The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell's C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95
KW  - Humans
KW  - Healthy Lifestyle
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Neoplasms: mortality
KW  - Neoplasms: epidemiology
KW  - Cardiovascular Diseases: mortality
KW  - Cardiovascular Diseases: epidemiology
KW  - Prospective Studies
KW  - Aged
KW  - Adult
KW  - Diabetes Mellitus, Type 2: mortality
KW  - Diabetes Mellitus, Type 2: epidemiology
KW  - Risk Factors
KW  - Proportional Hazards Models
KW  - Europe: epidemiology
KW  - Mortality, Premature
KW  - Life Style
KW  - Cancer (Other)
KW  - Cardiovascular diseases (Other)
KW  - Composite score (Other)
KW  - Healthy lifestyle index (Other)
KW  - Lifestyle factors (Other)
KW  - Mortality (Other)
KW  - Type 2 diabetes (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39009699
C2  - pmc:PMC11250810
DO  - DOI:10.1038/s41598-024-66772-w
UR  - https://inrepo02.dkfz.de/record/291781
ER  -