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@ARTICLE{Godbole:291810,
      author       = {S. Godbole and H. Voß and A. Gocke and S. Schlumbohm and
                      Y. Schumann and B. Peng and M. Mynarek and S. Rutkowski and
                      M. Dottermusch and M. M. Dorostkar and A. Korshunov$^*$ and
                      T. Mair and S. Pfister$^*$ and M. Kwiatkowski and M. Hotze
                      and P. Neumann and C. Hartmann and J. Weis and F.
                      Liesche-Starnecker and Y. Guan and M. Moritz and B. Siebels
                      and N. Struve and H. Schlüter and U. Schüller and C. Krisp
                      and J. E. Neumann},
      title        = {{M}ultiomic profiling of medulloblastoma reveals
                      subtype-specific targetable alterations at the proteome and
                      {N}-glycan level.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-01522},
      pages        = {6237},
      year         = {2024},
      abstract     = {Medulloblastomas (MBs) are malignant pediatric brain tumors
                      that are molecularly and clinically heterogenous. The
                      application of omics technologies-mainly studying nucleic
                      acids-has significantly improved MB classification and
                      stratification, but treatment options are still
                      unsatisfactory. The proteome and their N-glycans hold the
                      potential to discover clinically relevant phenotypes and
                      targetable pathways. We compile a harmonized proteome
                      dataset of 167 MBs and integrate findings with DNA
                      methylome, transcriptome and N-glycome data. We show six
                      proteome MB subtypes, that can be assigned to two main
                      molecular programs: transcription/translation (pSHHt, pWNT
                      and pG3myc), and synapses/immunological processes (pSHHs,
                      pG3 and pG4). Multiomic analysis reveals different
                      conservation levels of proteome features across MB subtypes
                      at the DNA methylome level. Aggressive pGroup3myc MBs and
                      favorable pWNT MBs are most similar in cluster hierarchies
                      concerning overall proteome patterns but show different
                      protein abundances of the vincristine resistance-associated
                      multiprotein complex TriC/CCT and of N-glycan
                      turnover-associated factors. The N-glycome reflects proteome
                      subtypes and complex-bisecting N-glycans characterize
                      pGroup3myc tumors. Our results shed light on targetable
                      alterations in MB and set a foundation for potential
                      immunotherapies targeting glycan structures.},
      keywords     = {Medulloblastoma: metabolism / Medulloblastoma: genetics /
                      Humans / Polysaccharides: metabolism / Proteome: metabolism
                      / Cerebellar Neoplasms: metabolism / Cerebellar Neoplasms:
                      genetics / DNA Methylation / Transcriptome / Child /
                      Proteomics: methods / Female / Gene Expression Regulation,
                      Neoplastic / Male / Child, Preschool / Gene Expression
                      Profiling: methods / Polysaccharides (NLM Chemicals) /
                      Proteome (NLM Chemicals)},
      cin          = {B300 / HD01 / B062},
      ddc          = {500},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B062-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39043693},
      doi          = {10.1038/s41467-024-50554-z},
      url          = {https://inrepo02.dkfz.de/record/291810},
}