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@ARTICLE{Baum:291915,
      author       = {P. Baum and R. Cardoso$^*$ and J. Lenzi and R. A. M.
                      Damhuis and A. F. T. M. Verhagen and C. De Gendt and H.
                      Peacock and P. De Leyn and N. L. Christensen and K. Innos
                      and K. Oselin and V. Zadnik and T. Zagarv and H. Brenner$^*$
                      and H. Winter},
      title        = {{A}n {I}nternational {R}egistry {S}tudy of {E}arly-{S}tage
                      {NSCLC} treatment variations ({LUCAEUROPE}) in {E}urope and
                      the {USA} highlighting variations.},
      journal      = {European journal of cancer},
      volume       = {209},
      issn         = {0014-2964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01527},
      pages        = {114233},
      year         = {2024},
      abstract     = {Harmonized European NSCLC incidence, treatment approach,
                      and survival based on national tumor registries are
                      unclear.Surgery has the potential to cure NSCLC and
                      significantly prolong survival. This large-scale
                      international study aimed to investigate treatment
                      variations in Europe and the USA, as well as the
                      determinants for its utilization.The retrospective cohort
                      study analyzed data from six European national
                      population-based cancer registries (Belgium, Denmark,
                      Estonia, Germany, the Netherlands, and Slovenia) and the US
                      SEER database from 2010-2015.The study computed cancer
                      incidence, survival, and age-standardized proportions of the
                      use of various therapies. Multivariable logistic regression
                      models were used to assess associations between resection
                      and demographic and clinical parameters. A total of 428,107
                      records were analyzed. Among all countries, Estonia had the
                      highest surgical resection rate (79.3 $\%)$ and the lowest
                      radiation rate (7.3 $\%)$ for stage I patients. The
                      Netherlands had the highest rate of radiotherapy across all
                      years of investigation and the lowest surgery rate between
                      2012 and 2015. The primary treatment for early-stage NSCLC
                      showed significant international variation, with the USA
                      having a decrease in surgical rates from 67.6 $\%$ to 59.5
                      $\%.$ Resection was less frequently performed as tumor stage
                      increased, patients aged, other lung cancer besides
                      adenocarcinoma was present, and when the tumor site
                      overlapped multiple lobes.Resection rates have declined in
                      some studied European countries and the USA and resection
                      rates vary substantially among countries. Interpretation of
                      current scientific lung cancer evidence and international
                      guidelines results in wide variations in patient treatment.},
      keywords     = {Incidence (Other) / Lung cancer (Other) / Radiotherapy
                      (Other) / SBRT (Other) / Surgery (Other) / Survival (Other)},
      cin          = {C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39053290},
      doi          = {10.1016/j.ejca.2024.114233},
      url          = {https://inrepo02.dkfz.de/record/291915},
}