TY  - JOUR
AU  - Sha, Sha
AU  - Degen, Miriam
AU  - Vlaski, Tomislav
AU  - Fan, Ziwen
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - The Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis.
JO  - Nutrients
VL  - 16
IS  - 14
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2024-01529
SP  - 2251
PY  - 2024
N1  - #EA:C070#LA:C070#LA:C120#
AB  - Background: Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40-69, we examined associations of high 25-hydroxyvitamin (25(OH)D) levels ≥ 100 nmol/L and vitamin D supplementation with hypercalcemia (serum calcium > 2.6 mmol/L), kidney stones, and atherosclerosis assessments (pulse wave arterial stiffness index and carotid intima-medial thickness). Regression models were comprehensively adjusted for 49 covariates. Results: Approximately 1.5
KW  - Humans
KW  - Hypercalcemia: epidemiology
KW  - Hypercalcemia: chemically induced
KW  - Vitamin D: analogs & derivatives
KW  - Vitamin D: blood
KW  - Vitamin D: administration & dosage
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Dietary Supplements: adverse effects
KW  - United Kingdom: epidemiology
KW  - Kidney Calculi: epidemiology
KW  - Kidney Calculi: blood
KW  - Aged
KW  - Atherosclerosis: epidemiology
KW  - Atherosclerosis: etiology
KW  - Adult
KW  - Prevalence
KW  - Biological Specimen Banks
KW  - Risk Factors
KW  - Calcium: blood
KW  - Calcium: administration & dosage
KW  - UK Biobank
KW  - adverse events (Other)
KW  - atherosclerosis (Other)
KW  - hypercalcemia (Other)
KW  - kidney stone risk (Other)
KW  - real-world evidence (Other)
KW  - serum 25-hydroxyvitamin D levels (Other)
KW  - vitamin D supplementation (Other)
KW  - Vitamin D (NLM Chemicals)
KW  - 25-hydroxyvitamin D (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39064694
C2  - pmc:PMC11279740
DO  - DOI:10.3390/nu16142251
UR  - https://inrepo02.dkfz.de/record/291917
ER  -