TY  - JOUR
AU  - Hiensch, Anouk E
AU  - Depenbusch, Johanna
AU  - Schmidt, Martina
AU  - Monninkhof, Evelyn M
AU  - Pelaez, Mireia
AU  - Clauss, Dorothea
AU  - Gunasekara, Nadira
AU  - Zimmer, Philipp
AU  - Belloso, Jon
AU  - Trevaskis, Mark
AU  - Rundqvist, Helene
AU  - Wiskemann, Joachim
AU  - Müller, Jana
AU  - Sweegers, Maike G
AU  - Fremd, Carlo
AU  - Altena, Renske
AU  - Gorecki, Maciej
AU  - Bijlsma, Rhodé
AU  - van Leeuwen-Snoeks, Lobke
AU  - Ten Bokkel Huinink, Daan
AU  - Sonke, Gabe
AU  - Lahuerta, Ainhara
AU  - Mann, G Bruce
AU  - Francis, Prudence A
AU  - Richardson, Gary
AU  - Malter, Wolfram
AU  - van der Wall, Elsken
AU  - Aaronson, Neil K
AU  - Senkus, Elzbieta
AU  - Urruticoechea, Ander
AU  - Zopf, Eva M
AU  - Bloch, Wilhelm
AU  - Stuiver, Martijn M
AU  - Wengstrom, Yvonne
AU  - Steindorf, Karen
AU  - May, Anne M
TI  - Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial.
JO  - Nature medicine
VL  - 30
IS  - 10
SN  - 1078-8956
CY  - New York, NY
PB  - Nature America Inc.
M1  - DKFZ-2024-01563
SP  - 2957-2966
PY  - 2024
N1  - #EA:C110# / 2024 Oct;30(10):2957-2966
AB  - Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ≥6 months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n = 179) or a 9-month supervised exercise program (exercise group, n = 178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9 months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (-5.3 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:39054374
DO  - DOI:10.1038/s41591-024-03143-y
UR  - https://inrepo02.dkfz.de/record/291980
ER  -