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@ARTICLE{Hiensch:291980,
      author       = {A. E. Hiensch$^*$ and J. Depenbusch$^*$ and M. Schmidt$^*$
                      and E. M. Monninkhof and M. Pelaez and D. Clauss and N.
                      Gunasekara and P. Zimmer and J. Belloso and M. Trevaskis and
                      H. Rundqvist and J. Wiskemann and J. Müller and M. G.
                      Sweegers and C. Fremd$^*$ and R. Altena and M. Gorecki and
                      R. Bijlsma and L. van Leeuwen-Snoeks and D. Ten Bokkel
                      Huinink and G. Sonke and A. Lahuerta and G. B. Mann and P.
                      A. Francis and G. Richardson and W. Malter and E. van der
                      Wall and N. K. Aaronson and E. Senkus and A. Urruticoechea
                      and E. M. Zopf and W. Bloch and M. M. Stuiver and Y.
                      Wengstrom and K. Steindorf$^*$ and A. M. May},
      title        = {{S}upervised, structured and individualized exercise in
                      metastatic breast cancer: a randomized controlled trial.},
      journal      = {Nature medicine},
      volume       = {30},
      number       = {10},
      issn         = {1078-8956},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DKFZ-2024-01563},
      pages        = {2957-2966},
      year         = {2024},
      note         = {#EA:C110# / 2024 Oct;30(10):2957-2966},
      abstract     = {Physical exercise both during and after curative cancer
                      treatment has been shown to reduce side effects. Evidence in
                      the metastatic cancer setting is scarce, and interventions
                      that improve health-related quality of life (HRQOL) are much
                      needed for patients with metastatic breast cancer (MBC). The
                      multinational randomized controlled PREFERABLE-EFFECT trial
                      assessed the effects of exercise on fatigue and HRQOL in
                      patients with MBC. In total, 357 patients with MBC and a
                      life expectancy of ≥6 months but without unstable bone
                      metastases were recruited at eight study centers across five
                      European countries and Australia. Participants were randomly
                      assigned (1:1) to usual care (control group, n = 179) or a
                      9-month supervised exercise program (exercise group, n =
                      178). Intervention effects on physical fatigue (European
                      Organization for Research and Treatment of Cancer (EORTC)
                      Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL
                      (EORTC QLQ-C30 summary score) were determined by comparing
                      the change from baseline to 3, 6 (primary timepoint) and 9
                      months between groups using mixed models for repeated
                      measures, adjusted for baseline values of the outcome, line
                      of treatment (first or second versus third or higher) and
                      study center. Exercise resulted in significant positive
                      effects on both primary outcomes. Physical fatigue was
                      significantly lower (-5.3 $(95\%$ confidence interval (CI),
                      -10.0 to -0.6), Bonferroni-Holm-adjusted P = 0.027; Cohen's
                      effect size, 0.22) and HRQOL significantly higher (4.8
                      $(95\%$ CI, 2.2-7.4), Bonferroni-Holm-adjusted P = 0.0003;
                      effect size, 0.33) in the exercise group than in the control
                      group at 6 months. Two serious adverse events occurred (that
                      is, fractures), but both were not related to bone
                      metastases. These results demonstrate that supervised
                      exercise has positive effects on physical fatigue and HRQOL
                      in patients with MBC and should be recommended as part of
                      supportive care.ClinicalTrials.gov Identifier: NCT04120298
                      .},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39054374},
      doi          = {10.1038/s41591-024-03143-y},
      url          = {https://inrepo02.dkfz.de/record/291980},
}