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@ARTICLE{Hemminki:292073,
      author       = {K. Hemminki$^*$ and F. Zitricky and A. Försti$^*$ and O.
                      Hemminki and V. Liska and A. Hemminki},
      title        = {{S}urvival improvements in esophageal and gastric cancers
                      in the {N}ordic countries favor younger patients.},
      journal      = {Cancer medicine},
      volume       = {13},
      number       = {15},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-01581},
      pages        = {e7365},
      year         = {2024},
      note         = {#EA:Z999#},
      abstract     = {Esophageal cancer (EC) and gastric cancer (GC) are fatal
                      cancers with a relatively late age of onset. Age is a
                      negative risk factor for survival in many cancers and our
                      aim was to analyze age-specific survival in EC and GC using
                      the recently updated NORDCAN database. NORDCAN data
                      originate from the Danish, Finnish, Norwegian, and Swedish
                      nationwide cancer registries covering years 1972 through
                      2021 inviting for comparison of 50-year survival trends
                      between the countries. Relative 1- and 5-year survival and
                      5/1-year conditional survival (i.e., survival in those who
                      were alive in Year 1 to survive additional 4 years) were
                      analyzed. Survival in EC showed large gains for patients
                      below age 80 years, 5-year survival in Norwegian men
                      reaching $30\%$ and in women over $30\%$ but for 80-89 year
                      old survival remained at $10\%.$ In contrast, hardly any
                      gain was seen among the 80-89 year patients for 1-year
                      survival and small gains in 5 year and 5/1-year survival.
                      Survival gaps between age-groups increased over time. For GC
                      there was also a clear age-related negative survival
                      gradient but the survival gaps between the age groups did
                      not widen over time; Norwegian male and female 5-year
                      survival for 80-89 year old was about $20\%.$ The
                      age-specific survival difference in GC arose in Year 1 and
                      did not essentially increase in 5-year survival. While there
                      were differences in survival improvements between the
                      countries, poor survival of the 80-89 year old patients was
                      shared by all of them. To conclude, survival has improved
                      steadily in younger GC and EC patients in most Nordic
                      countries. While the 80-89 year old population accounts for
                      nearly a quarter of all patients and their poor survival
                      depressed overall survival, which can therefore be increased
                      further by improving diagnostics, treatment and care of
                      elderly EC and GC patients.},
      keywords     = {Humans / Esophageal Neoplasms: mortality / Esophageal
                      Neoplasms: epidemiology / Stomach Neoplasms: mortality /
                      Stomach Neoplasms: epidemiology / Male / Female / Aged, 80
                      and over / Aged / Middle Aged / Age Factors / Registries /
                      Scandinavian and Nordic Countries: epidemiology / Adult /
                      Survival Rate / mortality (Other) / relative survival
                      (Other) / risk factors (Other) / stomach cancer (Other) /
                      treatment (Other)},
      cin          = {Z999 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)Z999-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39096090},
      pmc          = {pmc:PMC11297530},
      doi          = {10.1002/cam4.7365},
      url          = {https://inrepo02.dkfz.de/record/292073},
}