TY  - JOUR
AU  - Li, Jinze
AU  - Roshelli Baker, Jacqueline
AU  - Aglago, Elom K
AU  - Zhao, Zhiwei
AU  - Jiao, Li
AU  - Freisling, Heinz
AU  - Hughes, David J
AU  - Eriksen, Anne Kirstine
AU  - Tjønneland, Anne
AU  - Severi, Gianluca
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Pala, Valeria
AU  - Pasanisi, Fabrizio
AU  - Tumino, Rosario
AU  - Padroni, Lisa
AU  - Vermeulen, Roel C H
AU  - Gram, Inger T
AU  - Braaten, Tonje
AU  - Jakszyn, Paula Gabriela
AU  - Sánchez, Maria-José
AU  - Gómez-Gómez, Jesús-Humberto
AU  - Moreno-Iribas, Conchi
AU  - Amiano, Pilar
AU  - Papier, Keren
AU  - Weiderpass, Elisabete
AU  - Huybrechts, Inge
AU  - Heath, Alicia K
AU  - Schalkwijk, Casper
AU  - Jenab, Mazda
AU  - Fedirko, Veronika
TI  - Pre-diagnostic plasma advanced glycation end-products and soluble receptor for advanced glycation end-products and mortality in colorectal cancer patients.
JO  - International journal of cancer
VL  - 155
IS  - 11
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2024-01582
SP  - 1982-1995
PY  - 2024
N1  - 2024 Dec 1;155(11):1982-1995
AB  - Advanced glycation end-products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre-diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC-specific and overall mortality were estimated using multivariable-adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Concentrations of major plasma AGEs, Nε-[carboxy-methyl]lysine (CML), Nε-[carboxy-ethyl]lysine (CEL) and Nδ-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), were measured using ultra-performance liquid chromatography mass-spectrometry. sRAGE was assessed by enzyme-linked immunosorbent assay. Over a mean follow-up period of 96 months, 693 deaths occurred of which 541 were due to CRC. Individual and combined AGEs were not statistically significantly associated with CRC-specific or overall mortality. However, there was a possible interaction by sex for CEL (Pinteraction = .05). Participants with higher sRAGE had a higher risk of dying from CRC (HRQ5vs.Q1 = 1.67, 95
KW  - advanced glycation end‐products (AGEs) (Other)
KW  - colorectal cancer (Other)
KW  - mortality (Other)
KW  - soluble receptor of AGEs (sRAGE) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39057841
DO  - DOI:10.1002/ijc.35114
UR  - https://inrepo02.dkfz.de/record/292074
ER  -