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@ARTICLE{Li:292074,
      author       = {J. Li and J. Roshelli Baker and E. K. Aglago and Z. Zhao
                      and L. Jiao and H. Freisling and D. J. Hughes and A. K.
                      Eriksen and A. Tjønneland and G. Severi and V. Katzke$^*$
                      and R. Kaaks$^*$ and M. B. Schulze and G. Masala and V. Pala
                      and F. Pasanisi and R. Tumino and L. Padroni and R. C. H.
                      Vermeulen and I. T. Gram and T. Braaten and P. G. Jakszyn
                      and M.-J. Sánchez and J.-H. Gómez-Gómez and C.
                      Moreno-Iribas and P. Amiano and K. Papier and E. Weiderpass
                      and I. Huybrechts and A. K. Heath and C. Schalkwijk and M.
                      Jenab and V. Fedirko},
      title        = {{P}re-diagnostic plasma advanced glycation end-products and
                      soluble receptor for advanced glycation end-products and
                      mortality in colorectal cancer patients.},
      journal      = {International journal of cancer},
      volume       = {155},
      number       = {11},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01582},
      pages        = {1982-1995},
      year         = {2024},
      note         = {2024 Dec 1;155(11):1982-1995},
      abstract     = {Advanced glycation end-products (AGEs), formed endogenously
                      or obtained exogenously from diet, may contribute to chronic
                      inflammation, intracellular signaling alterations, and
                      pathogenesis of several chronic diseases including
                      colorectal cancer (CRC). However, the role of AGEs in CRC
                      survival is less known. The associations of pre-diagnostic
                      circulating AGEs and their soluble receptor (sRAGE) with
                      CRC-specific and overall mortality were estimated using
                      multivariable-adjusted Cox proportional hazards regression
                      among 1369 CRC cases in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study.
                      Concentrations of major plasma AGEs,
                      Nε-[carboxy-methyl]lysine (CML), Nε-[carboxy-ethyl]lysine
                      (CEL) and Nδ-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine
                      (MG-H1), were measured using ultra-performance liquid
                      chromatography mass-spectrometry. sRAGE was assessed by
                      enzyme-linked immunosorbent assay. Over a mean follow-up
                      period of 96 months, 693 deaths occurred of which 541 were
                      due to CRC. Individual and combined AGEs were not
                      statistically significantly associated with CRC-specific or
                      overall mortality. However, there was a possible interaction
                      by sex for CEL (Pinteraction = .05). Participants with
                      higher sRAGE had a higher risk of dying from CRC (HRQ5vs.Q1
                      = 1.67, $95\%$ CI: 1.21-2.30, Ptrend = .02) or any cause
                      (HRQ5vs.Q1 = 1.38, $95\%$ CI: 1.05-1.83, Ptrend = .09).
                      These associations tended to be stronger among cases with
                      diabetes (Pinteraction = .03) and pre-diabetes (Pinteraction
                      <.01) before CRC diagnosis. Pre-diagnostic AGEs were not
                      associated with CRC-specific and overall mortality in
                      individuals with CRC. However, a positive association was
                      observed for sRAGE. Our findings may stimulate further
                      research on the role of AGEs and sRAGE in survival among
                      cancer patients with special emphasis on potential effect
                      modifications by sex and diabetes.},
      keywords     = {advanced glycation end‐products (AGEs) (Other) /
                      colorectal cancer (Other) / mortality (Other) / soluble
                      receptor of AGEs (sRAGE) (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39057841},
      doi          = {10.1002/ijc.35114},
      url          = {https://inrepo02.dkfz.de/record/292074},
}