TY  - JOUR
AU  - Kaulen, Leon
AU  - Hielscher, Thomas
AU  - Doubrovinskaia, Sofia
AU  - Hoffmann, Dirk Carsten Frieder
AU  - Kessler, Tobias
AU  - Traub, Benjamin-Leon
AU  - Baehring, Joachim M
AU  - Wick, Wolfgang
TI  - Clinical Presentation, Management, and Outcome in Neurolymphomatosis: A Systematic Review.
JO  - Neurology
VL  - 103
IS  - 4
SN  - 0028-3878
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DKFZ-2024-01590
SP  - e209698
PY  - 2024
N1  - #EA:B320#LA:B320#
AB  - Neurolymphomatosis (NL) refers to lymphomatous infiltration of the peripheral nervous system (PNS). NL diagnosis and treatment are challenging given the broad differential diagnosis of peripheral neuropathy, the lack of larger cohorts, and the subsequent unavailability of prognostic factors or consensus therapy. This study aimed to define characteristics and prognostic factors of NL.A systematic review of the literature (2004-2023) was performed using PubMed and Scopus databases and reported following PRISMA guidelines. Studies reporting individual patient data on cases with definitive NL diagnosis were included. Clinical, radiologic, pathologic, and outcome information were extracted. Univariable and multivariable survival analyses were performed using log-rank tests and Cox proportional hazard models.A total of 459 NL cases from 264 studies were accumulated. NL was the first manifestation of malignancy (primary NL) in 197 patients. PNS relapse of known non-Hodgkin lymphoma (secondary NL) occurred in 262 cases after a median 12 months. NL predominantly presented with rapidly deteriorating, asymmetric painful polyneuropathy. Infiltrated structures included peripheral nerves (56
KW  - Humans
KW  - Neurolymphomatosis: therapy
KW  - Neurolymphomatosis: diagnostic imaging
KW  - Disease Management
KW  - Prognosis
LB  - PUB:(DE-HGF)16
C6  - pmid:39102613
DO  - DOI:10.1212/WNL.0000000000209698
UR  - https://inrepo02.dkfz.de/record/292086
ER  -