%0 Journal Article
%A Laban, Hebatullah
%A Siegmund, Sophia
%A Schlereth, Katharina
%A Trogisch, Felix A
%A Ablieh, Alia
%A Brandenburg, Lennart
%A Weigert, Andreas
%A De La Torre, Carolina
%A Mogler, Carolin
%A Hecker, Markus
%A Kuebler, Wolfgang M
%A Korff, Thomas
%T Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia.
%J Cardiovascular research
%V 120
%N 13
%@ 0008-6363
%C Oxford
%I Oxford University Press
%M DKFZ-2024-01599
%P 1590-1606
%D 2024
%Z 2024 Nov 5;120(13):1590-1606 / (DKFZ-ZMBH Alliance)
%X Chronic hypoxia causes detrimental structural alterations in the lung, which may cause pulmonary hypertension and are partially mediated by the endothelium. While its relevance for the development of hypoxia-associated lung diseases is well known, determinants controlling the initial adaptation of the lung endothelium to hypoxia remain largely unexplored.We revealed that hypoxia activates the transcription factor nuclear factor of activated T-cells 5 (NFAT5) and studied its regulatory function in murine lung endothelial cells (MLECs). EC-specific knockout of Nfat5 (Nfat5(EC)-/-) in mice exposed to normobaric hypoxia (10
%K Endothelial cells (Other)
%K Hypoxia (Other)
%K NFAT5 (Other)
%K Pulmonary hypertension (Other)
%K Transcriptome (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39107245
%R 10.1093/cvr/cvae151
%U https://inrepo02.dkfz.de/record/292100