TY  - JOUR
AU  - Laban, Hebatullah
AU  - Siegmund, Sophia
AU  - Schlereth, Katharina
AU  - Trogisch, Felix A
AU  - Ablieh, Alia
AU  - Brandenburg, Lennart
AU  - Weigert, Andreas
AU  - De La Torre, Carolina
AU  - Mogler, Carolin
AU  - Hecker, Markus
AU  - Kuebler, Wolfgang M
AU  - Korff, Thomas
TI  - Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia.
JO  - Cardiovascular research
VL  - 120
IS  - 13
SN  - 0008-6363
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2024-01599
SP  - 1590-1606
PY  - 2024
N1  - 2024 Nov 5;120(13):1590-1606 / (DKFZ-ZMBH Alliance)
AB  - Chronic hypoxia causes detrimental structural alterations in the lung, which may cause pulmonary hypertension and are partially mediated by the endothelium. While its relevance for the development of hypoxia-associated lung diseases is well known, determinants controlling the initial adaptation of the lung endothelium to hypoxia remain largely unexplored.We revealed that hypoxia activates the transcription factor nuclear factor of activated T-cells 5 (NFAT5) and studied its regulatory function in murine lung endothelial cells (MLECs). EC-specific knockout of Nfat5 (Nfat5(EC)-/-) in mice exposed to normobaric hypoxia (10
KW  - Endothelial cells (Other)
KW  - Hypoxia (Other)
KW  - NFAT5 (Other)
KW  - Pulmonary hypertension (Other)
KW  - Transcriptome (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39107245
DO  - DOI:10.1093/cvr/cvae151
UR  - https://inrepo02.dkfz.de/record/292100
ER  -