%0 Journal Article
%A Weichenhan, Dieter
%A Riedel, Anna
%A Sollier, Etienne
%A Toprak, Umut
%A Hey, Joschka
%A Breuer, Kersten
%A Wierzbinska, Justyna Anna
%A Touzart, Aurore
%A Lutsik, Pavlo
%A Bähr, Marion
%A Östlund, Anders
%A Nilsson, Tina
%A Jacobsson, Susanna
%A Waraky, Ahmed
%A Behrens, Yvonne Lisa
%A Göhring, Gudrun
%A Schlegelberger, Brigitte
%A Steinek, Clemens
%A Harz, Hartmann
%A Leonhardt, Heinrich
%A Dolnik, Anna
%A Reinhardt, Dirk
%A Bullinger, Lars
%A Palmqvist, Lars
%A Lipka, Daniel
%A Plass, Christoph
%T Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).
%J Blood advances
%V 8
%N 19
%@ 2473-9529
%C Washington, DC
%I American Society of Hematology
%M DKFZ-2024-01633
%P 5100-5111
%D 2024
%Z #EA:B370#EA:B087#LA:B370#LA:B340# / 2024 Oct 8;8(19):5100-5111
%X Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between breakpoint partners (MNX1 and ETV6) has only been reported in a subset of cases. However, a universal feature is the strong transcript and protein expression of MNX1, a homeobox transcription factor that is normally not expressed in hematopoietic cells. Here, we map the translocation breakpoints on chromosomes 7 and 12 in affected patients to a region proximal to MNX1 and either introns 1 or 2 of ETV6. The frequency of MNX1 overexpression in pediatric AML (n=1556, own and published data) is 2.4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39121370
%R 10.1182/bloodadvances.2023012161
%U https://inrepo02.dkfz.de/record/292145