TY  - JOUR
AU  - Weichenhan, Dieter
AU  - Riedel, Anna
AU  - Sollier, Etienne
AU  - Toprak, Umut
AU  - Hey, Joschka
AU  - Breuer, Kersten
AU  - Wierzbinska, Justyna Anna
AU  - Touzart, Aurore
AU  - Lutsik, Pavlo
AU  - Bähr, Marion
AU  - Östlund, Anders
AU  - Nilsson, Tina
AU  - Jacobsson, Susanna
AU  - Waraky, Ahmed
AU  - Behrens, Yvonne Lisa
AU  - Göhring, Gudrun
AU  - Schlegelberger, Brigitte
AU  - Steinek, Clemens
AU  - Harz, Hartmann
AU  - Leonhardt, Heinrich
AU  - Dolnik, Anna
AU  - Reinhardt, Dirk
AU  - Bullinger, Lars
AU  - Palmqvist, Lars
AU  - Lipka, Daniel
AU  - Plass, Christoph
TI  - Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).
JO  - Blood advances
VL  - 8
IS  - 19
SN  - 2473-9529
CY  - Washington, DC
PB  - American Society of Hematology
M1  - DKFZ-2024-01633
SP  - 5100-5111
PY  - 2024
N1  - #EA:B370#EA:B087#LA:B370#LA:B340# / 2024 Oct 8;8(19):5100-5111
AB  - Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between breakpoint partners (MNX1 and ETV6) has only been reported in a subset of cases. However, a universal feature is the strong transcript and protein expression of MNX1, a homeobox transcription factor that is normally not expressed in hematopoietic cells. Here, we map the translocation breakpoints on chromosomes 7 and 12 in affected patients to a region proximal to MNX1 and either introns 1 or 2 of ETV6. The frequency of MNX1 overexpression in pediatric AML (n=1556, own and published data) is 2.4
LB  - PUB:(DE-HGF)16
C6  - pmid:39121370
DO  - DOI:10.1182/bloodadvances.2023012161
UR  - https://inrepo02.dkfz.de/record/292145
ER  -